| Gene Symbol |
RCOR1
|
| Entrez Gene |
23186
|
| Alt Symbol |
COREST, RCOR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
REST corepressor 1
|
| Other Description |
-
|
| Swissprots |
Q86VG5 Q6P2I9 Q15044 Q9UKL0
|
| Accessions |
EAW81793 EAW81794 Q9UKL0 AF070627 AF155595 AAF01498 AI337324 AK026612 BC051003 AAH51003 BC064495 AAH64495 BC111590 AAI11591 D31888 BAA06686 DB455887 XM_005267453 XP_005267510 XR_943406 NM_015156 NP_055971
|
| Function |
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10449787}.
|
| Top Pathways |
Huntington's disease
|