RCOR1

Gene Symbol RCOR1
Entrez Gene 23186
Alt Symbol COREST, RCOR
Species Human
Gene Type protein-coding
Description REST corepressor 1
Other Description -
Swissprots Q86VG5 Q6P2I9 Q15044 Q9UKL0
Accessions EAW81793 EAW81794 Q9UKL0 AF070627 AF155595 AAF01498 AI337324 AK026612 BC051003 AAH51003 BC064495 AAH64495 BC111590 AAI11591 D31888 BAA06686 DB455887 XM_005267453 XP_005267510 XR_943406 NM_015156 NP_055971
Function Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10449787}.
Top Pathways Huntington's disease

CoREST CRISPR/Cas9 KO Plasmid (h) - sc-402066 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST HDR Plasmid (h) - sc-402066-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST Double Nickase Plasmid (h) - sc-402066-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST Double Nickase Plasmid (h2) - sc-402066-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST CRISPR Activation Plasmid (h) - sc-402066-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST CRISPR Activation Plasmid (h2) - sc-402066-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST Lentiviral Activation Particles (h) - sc-402066-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST Lentiviral Activation Particles (h2) - sc-402066-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CoREST siRNA (h) - sc-38131 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CoREST shRNA Plasmid (h) - sc-38131-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CoREST shRNA (h) Lentiviral Particles - sc-38131-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RCOR1/CoREST RNAi - H00023186-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU048871 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1516 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

RCOR1 siRNA (Human) - CRH8067 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RCOR1 - MBS8228181 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RCOR1 (NM_015156.3) - SHH391348 from Creative biogene

Category siRNA
Species Reactivities Human

Human RCOR1 siRNA - orb268569 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RCOR1 shRNA Plasmid (Human) - CHH8067 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RCOR1 miRNA 3'UTR clone - MiUTR4H-TG07417 from Creative biogene

Species Reactivities Human
Search more