RCOR1

Gene Symbol	RCOR1
Entrez Gene	23186
Alt Symbol	COREST, RCOR
Species	Human
Gene Type	protein-coding
Description	REST corepressor 1
Other Description	-
Swissprots	Q86VG5 Q6P2I9 Q15044 Q9UKL0
Accessions	EAW81793 EAW81794 Q9UKL0 AF070627 AF155595 AAF01498 AI337324 AK026612 BC051003 AAH51003 BC064495 AAH64495 BC111590 AAI11591 D31888 BAA06686 DB455887 XM_005267453 XP_005267510 XR_943406 NM_015156 NP_055971
Function	Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:15897453}. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10449787}.
Top Pathways	Huntington's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CoREST full length protein - ab132151 from Abcam Category Protein Source Wheat germ Species Human

Human CoREST protein fragment - ab196077 from Abcam Category Protein Source E. coli Species Human

Mouse CoREST peptide - ab25741 from Abcam Category Peptide

RCOR1 / COREST Antibody Blocking Peptide - LS-E4655 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RCOR1 / COREST Antibody Blocking Peptide - LS-E12159 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RCOR1 / COREST Antibody Blocking Peptide - LS-E14128 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RCOR1/CoREST Protein - H00023186-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RCOR1-Antibody-N-term-Blocking-Peptide - BP17018a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RCOR1 - H00023186-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RCOR1 - H00023186-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CoREST, Active Human Recombinant Protein - GWB-EBBBD1 from Genway Biotech Category Protein Prices $600.00 Sizes 100 µg Species Human

Recombinant Human REST Corepressor 1, His-tagged - RCOR1-1852H from Creative Biomart Category Protein Source E.coli.

Recombinant Human REST corepressor 1(RCOR1) - CSB-YP019515HU CSB-EP019515HU CSB-BP019515HU CSB-MP019515HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human RCOR1 protein, His-tagged - RCOR1-71H from Creative Biomart Category Protein Source E.coli Species Human

RCOR1/CoREST Recombinant Protein Antigen - NBP2-38720PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CoREST Blocking Peptide (OESA09434) - OESA09434 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

RCOR1 Peptide, Human - M34GP13120H from Creative Peptides Category Peptide Source Synthetic. Species Human

RCOR1 fusion protein - Ag26770 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

REST corepressor 1 (RCOR1), Recombinant Protein - MBS1335814 from MyBioSource Category Protein Prices $1,265.00, $1,265.00, $1,485.00, $1,485.00, $2,070.00, $2,070.00, $2,535.00, $2,535.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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