| Gene Symbol |
IRX3
|
| Entrez Gene |
79191
|
| Alt Symbol |
IRX-1, IRXB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
iroquois homeobox 3
|
| Other Description |
homeodomain protein IRXB1|iroquois homeobox protein 3|iroquois-class homeodomain protein IRX-1|iroquois-class homeodomain protein IRX-3
|
| Swissprots |
Q8IVC6 Q7Z4A5 P78415 Q7Z4A4
|
| Accessions |
AAQ16548 EAW82815 P78415 AK309146 AY335943 AAQ16549 BC023667 AAH23667 BC034328 AAH34328 DQ892008 ABM82934 EU176666 ABW03467 U90308 AAB50006 XM_005256139 XP_005256196 NM_024336 NP_077312
|
| Function |
Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|