Gene Symbol | IRX3 |
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Entrez Gene | 79191 |
Alt Symbol | IRX-1, IRXB1 |
Species | Human |
Gene Type | protein-coding |
Description | iroquois homeobox 3 |
Other Description | homeodomain protein IRXB1|iroquois homeobox protein 3|iroquois-class homeodomain protein IRX-1|iroquois-class homeodomain protein IRX-3 |
Swissprots | Q8IVC6 Q7Z4A5 P78415 Q7Z4A4 |
Accessions | AAQ16548 EAW82815 P78415 AK309146 AY335943 AAQ16549 BC023667 AAH23667 BC034328 AAH34328 DQ892008 ABM82934 EU176666 ABW03467 U90308 AAB50006 XM_005256139 XP_005256196 NM_024336 NP_077312 |
Function | Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
IRX3 CRISPR/Cas9 KO Plasmid (h) - sc-404632 from Santa Cruz Biotechnology
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IRX3 HDR Plasmid (h) - sc-404632-HDR from Santa Cruz Biotechnology
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IRX3 Double Nickase Plasmid (h) - sc-404632-NIC from Santa Cruz Biotechnology
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IRX3 Double Nickase Plasmid (h2) - sc-404632-NIC-2 from Santa Cruz Biotechnology
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IRX3 CRISPR Activation Plasmid (h) - sc-404632-ACT from Santa Cruz Biotechnology
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IRX3 CRISPR Activation Plasmid (h2) - sc-404632-ACT-2 from Santa Cruz Biotechnology
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IRX3 Lentiviral Activation Particles (h) - sc-404632-LAC from Santa Cruz Biotechnology
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IRX3 Lentiviral Activation Particles (h2) - sc-404632-LAC-2 from Santa Cruz Biotechnology
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IRX3 siRNA (h) - sc-106756 from Santa Cruz Biotechnology
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IRX3 shRNA Plasmid (h) - sc-106756-SH from Santa Cruz Biotechnology
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IRX3 shRNA (h) Lentiviral Particles - sc-106756-V from Santa Cruz Biotechnology
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IRX3 RNAi - H00079191-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10779 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10779 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03494 from Sigma-Aldrich
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IRX3 siRNA (Human) - CRJ2357 from Cohesion Biosciences
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IRX3 - MBS8207478 from MyBioSource
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IRX3 CRISPR/Cas9 KO Plasmid (h2) - sc-404632-KO-2 from Santa Cruz Biotechnology
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IRX3 HDR Plasmid (h2) - sc-404632-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IRX3 (NM_024336.2) - SHH320821 from Creative biogene
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IRX3 shRNA Plasmid (Human) - CHJ2357 from Cohesion Biosciences
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IRX3 miRNA 3'UTR clone - MiUTR3H-12712 from Creative biogene
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