TGFBR2

Gene Symbol TGFBR2
Entrez Gene 7048
Alt Symbol AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
Species Human
Gene Type protein-coding
Description transforming growth factor, beta receptor II (70/80kDa)
Other Description TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II alpha|transforming growth factor, beta receptor II beta|transforming growth factor, beta receptor II delta|transforming growth factor, beta receptor II epsilon|transforming growth factor, beta receptor II gamma
Swissprots Q15580 B4DTV5 Q99474 Q6DKT6 P37173
Accessions AAB17553 AAB40916 AAT70724 ABG65632 ACZ58376 ACZ58377 CBX53837 CBX53838 EAW64410 EAW64411 EAW64412 P37173 AI279872 AJ786388 CAH10151 AK300383 BAG62117 AK304404 BAG65238 AK314102 BAG36796 AL554950 BC040499 BC152840 AAI52841 BI598781 BM457423 CA437785 CB988859 CD521609 D28131 BAA05673 DB493906 KC792576 AHI94910 KC792577 AHI94911 KC792578 AHI94912 KC792579 AHI94913 KC792580 AHI94914 M85079 AAA61164 XM_011534043 XP_011532345 XM_011534044 XP_011532346 XM_011534045 XP_011532347 NM_001024847 NP_001020018 NM_003242 NP_003233
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location Cell membrane {ECO:0000269|PubMed:1310899}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection

TGF-β Receptor II (D3A1) Rabbit mAb - 11888 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone D3A1
Western blot analysis of extracts from 293 and HT-1080 cells using TGF-β Receptor II (D3A1) Rabbit mAb.

TGF-β Receptor II (K105) Antibody - 3713 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with human TGF-β receptor II construct, using TGF-β Receptor II (K105) Antibody.

TGF-beta Receptor II Antibody - 2518 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Raji, RAW 264.7, and HT29 cells using TGF-beta Receptor II Antibody.

TGFβ RII (C-4) - sc-17791 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ RII (C-4): sc-17791. Western blot analysis of TGFβ RII expression in Hep G2 (A), A549 (B), TF-1 (C), 3T3-L1 (D), KNRK (E) and Mv 1 Lu (F) whole cell lysates.

TGFβ RII (D-2) - sc-17799 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ RII (D-2): sc-17799. Western blot analysis of TGFβ RII expression in A549 (A), 3T3-L1 (B) and KNRK (C) whole cell lysates.

TGFβ RII (E-6) - sc-17792 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TGFβ RII (E-6): sc-17792. Western blot analysis of HIS-tagged human recombinant TGFβ RII.

TGFβ RII (L-21) - sc-400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Immunoperoxidase staining of formalin-fixed, paraffin-embedded wounded ovine skin one day following excisional injury. Sections probed with TGFβ RII (C-16): sc-220 (A) and TGFβ RII (L-21): sc-400 (B). Kindly provided by Leslie Gold.

TGFβ RII (T-20) - sc-33929 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TGFβ RII (T-20): sc-33929. Western blot analysis of TGFβ RII expression in TF-1 (A) and WI 38 (B) whole cell lysates.

TGFβ RII (H-567) - sc-1700 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TGFβ RII (H-567): sc-1700. Western blot analysis of HIS-tagged human recombinant TGFβ RII.

TGFβ RII (C-16) - sc-220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Immunoperoxidase staining of formalin-fixed, paraffin-embedded wounded ovine skin one day following excisional injury. Sections probed with TGFβ RII (C-16): sc-220 (A) and TGFβ RII (L-21): sc-400 (B). Kindly provided by Leslie Gold.

p-TGFβ RII (Tyr 336) - sc-17006 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-TGFβ RII (Tyr 259) - sc-17005 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TGF beta Receptor II (phospho S225 + S250) antibody - ab192818 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling TGF beta Receptor II using ab192818 at a 1/50 dilution, the right image was pre-incubated with blocking peptide.

Anti-TGF beta Receptor II (phospho S225) antibody [EPR12198] - ab183037 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12198
All lanes : Anti-TGF beta Receptor II (phospho S225) antibody [EPR12198] (ab183037) at 1/10000 dilutionLane 1 : Lysate from HepG2 cells treated with TGF-ßLane 2 : Lysate from HepG2 cells treated with TGF-ß then treated with alkaline phosphataseLane 3 : Lysate from HepG2 cellsLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated antibody at 1/1000 dilution

Anti-TGF beta Receptor II (phospho S225/250) antibody - ab111564 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111564, at 1/50 dilution, staining TGF beta Receptor II in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-TGF beta Receptor II antibody - ab61213 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TGF beta Receptor II antibody (ab61213) at 1/500 dilutionLane 1 : extracts from NIH/3T3 cellsLane 2 : extracts from NIH/3T3 cells with immunizing peptide

Anti-TGF beta Receptor II antibody - ab186838 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186838. Blue DAPI for nuclear staining.

Anti-TGF beta Receptor II antibody - ab32798 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TGF beta Receptor II antibody - ab138248 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TGF beta Receptor II antibody (ab138248) at 1/500 dilution + HT-29 cell lysate at 30 µg

Anti-TGF beta Receptor II antibody [EPR14673] - ab184948 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14673
All lanes : Anti-TGF beta Receptor II antibody [EPR14673] (ab184948) at 1/5000 dilutionLane 1 : HepG2 cell lysateLane 2 : A549 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TGF beta Receptor II antibody [MM0056-4F14] - ab78419 from Abcam

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0056-4F14
ab78419 at 1/200 dilution, staining TGF beta Receptor II in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-TGFBR2 Antibody (aa77-148) - LS-C26489 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-TGFBR2 Antibody (aa27-85) - LS-C26488 from LifeSpan Bioscience

Prices $330.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-TGFBR2 Antibody (N-Terminus) - LS-C26378 from LifeSpan Bioscience

Prices $465.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-TGFBR2 Antibody (Extracellular Domain, Biotin) - LS-C126400 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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