| Gene Symbol |
TGFBR2
|
| Entrez Gene |
7048
|
| Alt Symbol |
AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor, beta receptor II (70/80kDa)
|
| Other Description |
TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II alpha|transforming growth factor, beta receptor II beta|transforming growth factor, beta receptor II delta|transforming growth factor, beta receptor II epsilon|transforming growth factor, beta receptor II gamma
|
| Swissprots |
Q15580 B4DTV5 Q99474 Q6DKT6 P37173
|
| Accessions |
AAB17553 AAB40916 AAT70724 ABG65632 ACZ58376 ACZ58377 CBX53837 CBX53838 EAW64410 EAW64411 EAW64412 P37173 AI279872 AJ786388 CAH10151 AK300383 BAG62117 AK304404 BAG65238 AK314102 BAG36796 AL554950 BC040499 BC152840 AAI52841 BI598781 BM457423 CA437785 CB988859 CD521609 D28131 BAA05673 DB493906 KC792576 AHI94910 KC792577 AHI94911 KC792578 AHI94912 KC792579 AHI94913 KC792580 AHI94914 M85079 AAA61164 XM_011534043 XP_011532345 XM_011534044 XP_011532346 XM_011534045 XP_011532347 NM_001024847 NP_001020018 NM_003242 NP_003233
|
| Function |
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:1310899}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}.
|
| Top Pathways |
TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection
|
