TGFBR2

Gene Symbol	TGFBR2
Entrez Gene	7048
Alt Symbol	AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
Species	Human
Gene Type	protein-coding
Description	transforming growth factor, beta receptor II (70/80kDa)
Other Description	TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II alpha|transforming growth factor, beta receptor II beta|transforming growth factor, beta receptor II delta|transforming growth factor, beta receptor II epsilon|transforming growth factor, beta receptor II gamma
Swissprots	Q15580 B4DTV5 Q99474 Q6DKT6 P37173
Accessions	AAB17553 AAB40916 AAT70724 ABG65632 ACZ58376 ACZ58377 CBX53837 CBX53838 EAW64410 EAW64411 EAW64412 P37173 AI279872 AJ786388 CAH10151 AK300383 BAG62117 AK304404 BAG65238 AK314102 BAG36796 AL554950 BC040499 BC152840 AAI52841 BI598781 BM457423 CA437785 CB988859 CD521609 D28131 BAA05673 DB493906 KC792576 AHI94910 KC792577 AHI94911 KC792578 AHI94912 KC792579 AHI94913 KC792580 AHI94914 M85079 AAA61164 XM_011534043 XP_011532345 XM_011534044 XP_011532346 XM_011534045 XP_011532347 NM_001024847 NP_001020018 NM_003242 NP_003233
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane {ECO:0000269|PubMed:1310899}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TGF beta R2 Human ELISA Kit - ab193715 from Abcam Category ELISA Kit Prices $475.00 Sizes 1 x 96 tests Sensitivity 1.5 pg/ml Range 1.5 pg/ml - 500 pg/ml

Human TGFBR2 / TGF-beta Receptor Type-2 ELISA Kit - RAB0553 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt Sensitivity 15 pg/ml

Mouse/Human TGFBR2 ELISA Kit (Cell-Based ELISA) - LS-F2348 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 16-1000 pg/ml

Human TGFBR2 ELISA Kit (Sandwich ELISA) - LS-F6708 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 16-1000 pg/ml

Human TGFBR2 ELISA Kit (Sandwich ELISA) - LS-F1007 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 16-1000 pg/ml

Mouse TGFBR2 ELISA Kit (Sandwich ELISA) - LS-F8659 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 16-1000 pg/ml

Human TGFBR2 ELISA Kit (Sandwich ELISA) - LS-F2967 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 16-1000 pg/ml

Human TGFBR2 ELISA Kit (Sandwich ELISA) - LS-F12747 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 16-1000 pg/ml

Human TGF-beta RII DuoSet ELISA - DY241 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

TGFβ-R2 ELISA Kit (Human) : 96 Wells (OKAG00165) - OKAG00165 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 16 pg/mL Range 16-1,000 pg/mL

TGF-beta receptor type-2 (TGFBR2), Human, ELISA Kit - E01T0684 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

TGF-beta receptor type-2, TGFBR2, Human, ELISA Kit - E9935h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

Transforming growth factor beta receptor 2 (TGF-bR2), Human, ELISA Kit - CSB-E13669h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Transforming Growth Factor Beta Receptor II (TGFbR2), Human, ELISA Kit - SEC972Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.126ng/mL. Range 0.312-20ng/mL

Human TGF-beta RII ELISA - ELH-TGFbR2 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 15 pg/ml Range 1.5 pg/ml - 500 pg/ml

TGFBR2, ELISA Kit - MBS177318 from MyBioSource Category ELISA Kit Prices $425.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 15.6pg/ml-1000pg/ml

TGF beta Receptor II Colorimetric Cell-Based ELISA Kit - CB5682 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

TGFbeta-R2 (Human) OmniKine™ ELISA Kit - OK-0266 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 16-1000 pg/ml

TGFBR2 (Human) ELISA Kit - DEIA4288 from Creative Diagnostics Category ELISA Kit

TGF beta receptor type 2 (TGFBR2), ELISA Kit - MBS7223133 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

TGF-beta receptor type-2 (TGFBR2), ELISA Kit - MBS7231746 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TGF-beta receptor type-2 (TGFBR2), ELISA Kit - MBS7244089 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TGF-beta receptor type-2 (TGFBR2), ELISA Kit - MBS7241032 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TGF-beta receptor type-2 (TGFBR2), ELISA Kit - MBS7233379 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TGF-beta receptor type-2 (TGFBR2), ELISA Kit - MBS7208563 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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