TGFBR2

Gene Symbol	TGFBR2
Entrez Gene	7048
Alt Symbol	AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
Species	Human
Gene Type	protein-coding
Description	transforming growth factor, beta receptor II (70/80kDa)
Other Description	TGF-beta receptor type IIB|TGF-beta receptor type-2|TGF-beta type II receptor|tbetaR-II|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II alpha|transforming growth factor, beta receptor II beta|transforming growth factor, beta receptor II delta|transforming growth factor, beta receptor II epsilon|transforming growth factor, beta receptor II gamma
Swissprots	Q15580 B4DTV5 Q99474 Q6DKT6 P37173
Accessions	AAB17553 AAB40916 AAT70724 ABG65632 ACZ58376 ACZ58377 CBX53837 CBX53838 EAW64410 EAW64411 EAW64412 P37173 AI279872 AJ786388 CAH10151 AK300383 BAG62117 AK304404 BAG65238 AK314102 BAG36796 AL554950 BC040499 BC152840 AAI52841 BI598781 BM457423 CA437785 CB988859 CD521609 D28131 BAA05673 DB493906 KC792576 AHI94910 KC792577 AHI94911 KC792578 AHI94912 KC792579 AHI94913 KC792580 AHI94914 M85079 AAA61164 XM_011534043 XP_011532345 XM_011534044 XP_011532346 XM_011534045 XP_011532347 NM_001024847 NP_001020018 NM_003242 NP_003233
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location	Cell membrane {ECO:0000269|PubMed:1310899}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active TGF beta Receptor II protein fragment - ab63173 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Insect cells

Human TGF beta Receptor II full length protein - ab132201 from Abcam Category Protein Source Wheat germ Species Human

Human TGF beta Receptor II peptide - ab134586 from Abcam Category Peptide Species Human

Human TGF beta Receptor II protein fragment - ab132200 from Abcam Category Protein Source Wheat germ Species Human

Human TGF beta Receptor II protein fragment - ab152747 from Abcam Category Protein Source Wheat germ Species Human

Human TGF beta Receptor II protein fragment - ab191920 from Abcam Category Protein Source HEK 293 cells Species Human

TGF beta Receptor II protein (Fc Chimera) - ab83578 from Abcam Category Protein Source HEK 293 cells Species Human

Human TGF beta Receptor II protein fragment - ab198081 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

TGFBR2 Antibody Blocking Peptide - LS-E1266 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGFBR2 Antibody Blocking Peptide - LS-E4932 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGFBR2 Antibody Blocking Peptide - LS-E16440 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TGF-beta RII Partial Recombinant Protein - H00007048-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TGF-beta RII Recombinant Protein - H00007048-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TGF-beta RII Recombinant Protein - H00007048-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TGFBR2-Antibody-N-term-Blocking-peptide - BP11854a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human TGF-beta RII - 241-R2-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ile24-Asp159

Recombinant Human TGF-beta RII, CF - 241-R2-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ile24-Asp159

Recombinant Human TGF-beta RII Fc Chimera, CF - 341-BR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human TGF-beta RII Isoform 2 Fc Chimera, CF - 1003-RT-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

TGFBR2 Protein (OPPA02170) - OPPA02170 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human TGF beta Receptor 2 protein - orb80871 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

Cynomolgus TGFBR2 protein - orb139733 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells

Human TGF beta Receptor 2 Fc His tag protein - orb83129 from Biorbyt Category Protein Prices $476.00, $748.00 Sizes 20 μg, 50 μg Source Human Species Human

Human TGFBR2 protein - orb180422 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293 Species Human

TGF beta Receptor 2 (phospho-S225) Peptide - orb224222 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit

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