| Gene Symbol |
SNX33
|
| Entrez Gene |
257364
|
| Alt Symbol |
SH3PX3, SH3PXD3C, SNX30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorting nexin 33
|
| Other Description |
SH3 and PX domain containing 3|SH3 and PX domain-containing protein 3|sorting nexin-33
|
| Swissprots |
B1NM17 Q8WV41
|
| Accessions |
CAL48182 CCQ43875 EAW99243 Q8WV41 AK091291 AK126563 AL833039 CAH56299 BC018775 AAH18775 DQ891695 ABM82621 DQ895211 ABM86137 EF219141 ABN09670 EF653821 ABV26009 EU831407 ACE87094 EU831499 ACE86418 NM_153271 NP_695003
|
| Function |
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
|
| Subcellular Location |
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:21048941}.
|
| Tissue Specificity |
Detected in heart and pancreas. {ECO:0000269|PubMed:18353773}.
|