| Gene Symbol |
TNRC6B
|
| Entrez Gene |
23112
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
trinucleotide repeat containing 6B
|
| Other Description |
trinucleotide repeat-containing gene 6B protein
|
| Swissprots |
B0QY78 B0QY73 B4DGC0 Q9UPQ9 Q5TH52 Q8TBX2
|
| Accessions |
EAW60367 EAW60368 EAW60369 EAW60370 EAW60371 EAW60372 EAW60373 Q9UPQ9 AB029016 BAA83045 AK294519 BAG57731 AK296590 BAG59207 AK304087 BAG64993 AL831862 BC028626 AAH28626 BC046218 BE501815 BG942870 BQ009349 BU584176 BX537577 BX647630 BX952326 CA312515 DB147781 NM_001024843 NP_001020014 NM_001162501 NP_001155973 NM_015088 NP_055903
|
| Function |
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051}. Note=Mammalian P-bodies are also known as GW bodies (GWBs).
|