Gene Symbol | TNRC6B |
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Entrez Gene | 23112 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | trinucleotide repeat containing 6B |
Other Description | trinucleotide repeat-containing gene 6B protein |
Swissprots | B0QY78 B0QY73 B4DGC0 Q9UPQ9 Q5TH52 Q8TBX2 |
Accessions | EAW60367 EAW60368 EAW60369 EAW60370 EAW60371 EAW60372 EAW60373 Q9UPQ9 AB029016 BAA83045 AK294519 BAG57731 AK296590 BAG59207 AK304087 BAG64993 AL831862 BC028626 AAH28626 BC046218 BE501815 BG942870 BQ009349 BU584176 BX537577 BX647630 BX952326 CA312515 DB147781 NM_001024843 NP_001020014 NM_001162501 NP_001155973 NM_015088 NP_055903 |
Function | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}. |
Subcellular Location | Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). |
Human TNRC6B protein fragment - ab161537 from Abcam
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TNRC6B Antibody Blocking Peptide - LS-E14691 from LifeSpan Bioscience
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TNRC6B Antibody Blocking Peptide - LS-E14955 from LifeSpan Bioscience
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Recombinant Human TNRC6B Protein - H00023112-Q02 from Novus Biologicals
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TNRC6B Blocking Peptide - 33R-10284 from Fitzgerald
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TNRC6B Blocking Peptide - 33R-5339 from Fitzgerald
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TNRC6B - H00023112-Q02-10 from Acris Antibodies
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TNRC6B - H00023112-Q02-25 from Acris Antibodies
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TNRC6B fusion protein - ag10955 from Proteintech Group
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TNRC6B fusion protein - Ag11644 from Proteintech Group
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Recombinant Human Trinucleotide repeat-containing gene 6B protein(TNRC6B) ,partial - CSB-YP892489HU CSB-EP892489HU CSB-BP892489HU CSB-MP892489HU from Cusabio
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TNRC6B Recombinant Protein Antigen - NBP1-81442PEP from Novus Biologicals
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TNRC6B Peptide, Human - M34GP16411H from Creative Peptides
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