Gene Symbol | TNRC6B |
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Entrez Gene | 23112 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | trinucleotide repeat containing 6B |
Other Description | trinucleotide repeat-containing gene 6B protein |
Swissprots | B0QY78 B0QY73 B4DGC0 Q9UPQ9 Q5TH52 Q8TBX2 |
Accessions | EAW60367 EAW60368 EAW60369 EAW60370 EAW60371 EAW60372 EAW60373 Q9UPQ9 AB029016 BAA83045 AK294519 BAG57731 AK296590 BAG59207 AK304087 BAG64993 AL831862 BC028626 AAH28626 BC046218 BE501815 BG942870 BQ009349 BU584176 BX537577 BX647630 BX952326 CA312515 DB147781 NM_001024843 NP_001020014 NM_001162501 NP_001155973 NM_015088 NP_055903 |
Function | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923}. |
Subcellular Location | Cytoplasm, P-body {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). |
TNRC6B CRISPR/Cas9 KO Plasmid (h) - sc-411669 from Santa Cruz Biotechnology
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TNRC6B HDR Plasmid (h) - sc-411669-HDR from Santa Cruz Biotechnology
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TNRC6B Double Nickase Plasmid (h) - sc-411669-NIC from Santa Cruz Biotechnology
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TNRC6B Double Nickase Plasmid (h2) - sc-411669-NIC-2 from Santa Cruz Biotechnology
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TNRC6B CRISPR Activation Plasmid (h) - sc-411669-ACT from Santa Cruz Biotechnology
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TNRC6B CRISPR Activation Plasmid (h2) - sc-411669-ACT-2 from Santa Cruz Biotechnology
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TNRC6B Lentiviral Activation Particles (h) - sc-411669-LAC from Santa Cruz Biotechnology
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TNRC6B Lentiviral Activation Particles (h2) - sc-411669-LAC-2 from Santa Cruz Biotechnology
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TNRC6B siRNA (h) - sc-76704 from Santa Cruz Biotechnology
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TNRC6B shRNA Plasmid (h) - sc-76704-SH from Santa Cruz Biotechnology
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TNRC6B shRNA (h) Lentiviral Particles - sc-76704-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU082731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21799 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21799 from Sigma-Aldrich
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TNRC6B siRNA (Human) - CRH8006 from Cohesion Biosciences
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TNRC6B - MBS8240763 from MyBioSource
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shRNA set against Human TNRC6B (NM_001024843.1) - SHH432548 from Creative biogene
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shRNA set against Human TNRC6B(NM_015088.2) - SHL043560 from Creative biogene
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shRNA set against Human TNRC6B(NM_001024843.1) - SHL043596 from Creative biogene
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Human TNRC6B siRNA - orb268508 from Biorbyt
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TNRC6B shRNA Plasmid (Human) - CHH8006 from Cohesion Biosciences
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TNRC6B miRNA 3'UTR clone - MiUTR1H-10632 from Creative biogene
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TNRC6B miRNA 3'UTR clone - MiUTR1H-10633 from Creative biogene
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