| Gene Symbol |
DOLPP1
|
| Entrez Gene |
57171
|
| Alt Symbol |
LSFR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dolichyldiphosphatase 1
|
| Other Description |
dolichyl pyrophosphate phosphatase 1|linked to Surfeit genes in Fugu rubripes 2
|
| Swissprots |
A8K3U8 B0QZG4 Q86YN1 Q9Y3G1 Q96GF8
|
| Accessions |
CAB44348 CAB44349 EAW87867 EAW87868 EAW87869 EAW87870 EAW87871 EAW87872 Q86YN1 AK290713 BAF83402 AK293627 BAG57084 AY189675 AAO34712 BC009493 AAH09493 BC022553 BC033686 AAH33686 BC040152 AAH40152 BC067858 DA590931 DQ655991 NM_001135917 NP_001129389 NM_020438 NP_065171 NR_072983
|
| Function |
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). {ECO:0000250|UniProtKB:Q9JMF7}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
N-Glycan biosynthesis
|