Gene Symbol | DOLPP1 |
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Entrez Gene | 57171 |
Alt Symbol | LSFR2 |
Species | Human |
Gene Type | protein-coding |
Description | dolichyldiphosphatase 1 |
Other Description | dolichyl pyrophosphate phosphatase 1|linked to Surfeit genes in Fugu rubripes 2 |
Swissprots | A8K3U8 B0QZG4 Q86YN1 Q9Y3G1 Q96GF8 |
Accessions | CAB44348 CAB44349 EAW87867 EAW87868 EAW87869 EAW87870 EAW87871 EAW87872 Q86YN1 AK290713 BAF83402 AK293627 BAG57084 AY189675 AAO34712 BC009493 AAH09493 BC022553 BC033686 AAH33686 BC040152 AAH40152 BC067858 DA590931 DQ655991 NM_001135917 NP_001129389 NM_020438 NP_065171 NR_072983 |
Function | Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity). {ECO:0000250|UniProtKB:Q9JMF7}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | N-Glycan biosynthesis |
DOLPP1 CRISPR/Cas9 KO Plasmid (h) - sc-412769 from Santa Cruz Biotechnology
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DOLPP1 HDR Plasmid (h) - sc-412769-HDR from Santa Cruz Biotechnology
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DOLPP1 Double Nickase Plasmid (h) - sc-412769-NIC from Santa Cruz Biotechnology
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DOLPP1 Double Nickase Plasmid (h2) - sc-412769-NIC-2 from Santa Cruz Biotechnology
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DOLPP1 CRISPR Activation Plasmid (h) - sc-412769-ACT from Santa Cruz Biotechnology
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DOLPP1 CRISPR Activation Plasmid (h2) - sc-412769-ACT-2 from Santa Cruz Biotechnology
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DOLPP1 Lentiviral Activation Particles (h) - sc-412769-LAC from Santa Cruz Biotechnology
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DOLPP1 Lentiviral Activation Particles (h2) - sc-412769-LAC-2 from Santa Cruz Biotechnology
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DOLPP1 siRNA (h) - sc-92552 from Santa Cruz Biotechnology
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DOLPP1 shRNA Plasmid (h) - sc-92552-SH from Santa Cruz Biotechnology
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DOLPP1 shRNA (h) Lentiviral Particles - sc-92552-V from Santa Cruz Biotechnology
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DOLPP1 RNAi - H00057171-R01 from Novus Biologicals
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MISSION® esiRNA - EHU086031 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0083 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0084 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0082 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7435 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7435 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09312 from Sigma-Aldrich
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DOLPP1 siRNA (Human) - CRJ1374 from Cohesion Biosciences
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DOLPP1 - MBS8214123 from MyBioSource
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shRNA set against Human DOLPP1 (NM_020438.4) - SHH280357 from Creative biogene
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Human DOLPP1 siRNA - orb271875 from Biorbyt
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DOLPP1 shRNA Plasmid (Human) - CHJ1374 from Cohesion Biosciences
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DOLPP1 miRNA 3'UTR clone - MiUTR3H-13154 from Creative biogene
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