RAB7B

Gene Symbol RAB7B
Entrez Gene 338382
Alt Symbol RAB7
Species Human
Gene Type protein-coding
Description RAB7B, member RAS oncogene family
Other Description Ras-related protein Rab-7|ras-related protein Rab-7b
Swissprots Q96AH8
Accessions EAW91589 EAW91590 EAW91591 Q96AH8 AI264357 AK122657 AK127140 AY094596 AAM22519 BC007382 BC017092 AAH17092 BI757251 BM671066 BX364514 DA966224 XM_006711288 XP_006711351 NM_001164522 NP_001157994 NM_001304839 NP_001291768 NM_177403 NP_796377
Function Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:20953574}.
Subcellular Location Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte. {ECO:0000269|PubMed:15144907}.
Top Pathways Phagosome, Amoebiasis, Salmonella infection

Rab 7b (JK-17) - sc-81922 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Rab 7b (JK-17): sc-81922. Western blot analysis of Rab 7b expression in HeLa whole cell lysate.

Anti-RAB7B antibody - ab58029 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
RAB7 antibody (ab58029) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-RAB7B antibody - ab76804 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Anti-RAB7B antibody (ab76804) at 5 µg/ml + Recombinant fragment of human RAB7B at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-RAB7B antibody - ab103544 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RAB7B antibody (ab103544) at 1 µg/ml + Human liver tissue lysate at 50 µg

Anti-RAB7B antibody - ab77064 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-RAB7B antibody (ab77064) at 5 µg/mlLane 1 : RAB7B transfected 293T cell lysateLane 2 : Non-transfected transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-RAB7B antibody [EPR15727] - ab193360 from Abcam

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15727
All lanes : Anti-RAB7B antibody [EPR15727] (ab193360) at 1/1000 dilutionLane 1 : THP-1 cell lysateLane 2 : 293 cell lysateLane 3 : U937 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-RAB7B antibody - C-terminal - ab156241 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RAB7B antibody - C-terminal (ab156241) at 1/100 dilution + A2058 cell line lysate at 35 µg

Anti-RAB7B Antibody (aa1-199) - LS-C131769 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197, AP) - LS-C239716 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197, APC) - LS-C239717 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197, Biotin) - LS-C239718 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197, FITC) - LS-C239719 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197, Azide-free, HRP) - LS-C248606 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-198) - LS-C324491 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197, PE) - LS-C239721 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7B Antibody (aa168-197) - LS-C155901 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RAB7B Antibody western blot of A2058 cell line lysates (35 ug/lane). The RAB7B antibody detected the RAB7B protein (arrow).

Anti-RAB7B Antibody (clone 1C3) - LS-C139323 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C3
Western blot of RAB7B expression in transfected 293T cell line by RAB7B monoclonal antibody (M02), clone 1C3.

RAB7B Antibody (3B3) - H00338382-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B3
Western Blot: RAB7B Antibody (3B3) [H00338382-M01] - RAB7B monoclonal antibody (M01), clone 3B3. Analysis of RAB7B expression in human kidney.

RAB7B Antibody - H00338382-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RAB7B Antibody [H00338382-D01P] - Analysis of RAB7B expression in human liver.

RAB7B Antibody - H00338382-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: RAB7B Antibody [H00338382-B01] - analysis of RAB7B expression in transfected 293T cell line by RAB7B MaxPab polyclonal antibody (B01). Lane 1: RAB7B transfected lysate (22.50 KDa). Lane 2: Non-transfected lysate.

RAB7B Antibody - H00338382-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RAB7B Antibody [H00338382-B01P] - Analysis of RAB7B expression in transfected 293T cell line by RAB7B polyclonal antibody. Lane 1: RAB7B transfected lysate(21.89 KDa). Lane 2: Non-transfected lysate.

RAB7B Antibody (1C3) - H00338382-M02 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C3

RAB7B Antibody (1C3) - H00338382-M02A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1C3

Monoclonal Anti-RAB7B, (C-terminal) antibody produced in mouse - SAB1405400 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C3
<B>Immunoblotting</B><BR/>Monoclonal Anti-RAB7B: <B>Cat. No. SAB1405400</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Monoclonal Anti-RAB7B antibody produced in mouse - WH0338382M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B3
<B>Immunoblotting</B><BR/>Monoclonal Anti-RAB7B, <B>Cat. No. WH0338382M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~22.5 kDa using HeLa lysate.
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