RAB7B

Gene Symbol	RAB7B
Entrez Gene	338382
Alt Symbol	RAB7
Species	Human
Gene Type	protein-coding
Description	RAB7B, member RAS oncogene family
Other Description	Ras-related protein Rab-7|ras-related protein Rab-7b
Swissprots	Q96AH8
Accessions	EAW91589 EAW91590 EAW91591 Q96AH8 AI264357 AK122657 AK127140 AY094596 AAM22519 BC007382 BC017092 AAH17092 BI757251 BM671066 BX364514 DA966224 XM_006711288 XP_006711351 NM_001164522 NP_001157994 NM_001304839 NP_001291768 NM_177403 NP_796377
Function	Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:20953574}.
Subcellular Location	Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity	Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte. {ECO:0000269|PubMed:15144907}.
Top Pathways	Phagosome, Amoebiasis, Salmonella infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAB7B full length protein - ab166249 from Abcam Category Protein Source Wheat germ Species Human

Human RAB7B protein fragment - ab166250 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human RAB7B Protein - H00338382-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RAB7B Protein - H00338382-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAB7A protein (His tag) - 80R-1636 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

RAB7B - H00338382-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB7B - H00338382-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB7B - H00338382-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAB7B - H00338382-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAB7B fusion protein - ag2936 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RAB7A Human - PRPS-084 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human RAB7B, GST-tagged - RAB7B-2133H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RAB7B, MYC/DDK-tagged - RAB7B-193H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Human RAB7B, MYC/DDK-tagged - RAB7B-195H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Human RAB7B, MYC/DDK-tagged - RAB7B-196H from Creative Biomart Category Protein Source HEK293 cells Species Human

RAB7A - NKX-011 from Reagent Proteins Category Protein Prices $364.00, $2,898.00 Sizes 20.00 µg, 1 mg Source E.coli

Rab7 Peptide - AP0030P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Ras-related protein Rab-7b(RAB7B) - CSB-YP853383HU CSB-EP853383HU CSB-BP853383HU CSB-MP853383HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAB7B fusion protein - Ag25035 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

RAB7B - TP302283 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RAB7B (transcript variant 2) - TP328755 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RAB7A, Member RAS Oncogene Family Human Recombinant - Pr21961 from ProMab Category Protein Prices $50.00, $130.00, $2,700.00 Sizes 5 μg, 20 μg, 1 mg Source Escherichia Coli. Species Human

RAB7B-Blocking-Peptide-C-term - BP19936B from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAB7B Peptide, Human - M34GP12878H from Creative Peptides Category Peptide Source Synthetic. Species Human

Ras-related protein Rab-7b (RAB7B), Recombinant Protein - MBS1343887 from MyBioSource Category Protein Prices $945.00, $945.00, $1,170.00, $1,170.00, $1,415.00, $1,415.00, $1,875.00, $1,875.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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