RAB7B

Gene Symbol RAB7B
Entrez Gene 338382
Alt Symbol RAB7
Species Human
Gene Type protein-coding
Description RAB7B, member RAS oncogene family
Other Description Ras-related protein Rab-7|ras-related protein Rab-7b
Swissprots Q96AH8
Accessions EAW91589 EAW91590 EAW91591 Q96AH8 AI264357 AK122657 AK127140 AY094596 AAM22519 BC007382 BC017092 AAH17092 BI757251 BM671066 BX364514 DA966224 XM_006711288 XP_006711351 NM_001164522 NP_001157994 NM_001304839 NP_001291768 NM_177403 NP_796377
Function Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:20953574}.
Subcellular Location Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
Tissue Specificity Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte. {ECO:0000269|PubMed:15144907}.
Top Pathways Phagosome, Amoebiasis, Salmonella infection

RAB7B (Human) IP-WB Antibody Pair - H00338382-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

RAB7B (Human) Matched Antibody Pair - H00338382-AP11 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

RAB7B (Human) Matched Antibody Pair - H00338382-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

RAB7A, Member RAS Oncogene Family (RAB7A), ELISA Kit - MBS2024918 from MyBioSource

Category ELISA Kit
Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.113ng/mL.
Range 0.313-20ng/mL

ELISA Kit for RAB7A, Member RAS Oncogene Family (RAB7A) - SEK300Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.113ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for RAB7, Member RAS Oncogene Family Like Protein 1 (RAB7L1) - EKU07004 from Biomatik

Category ELISA Kit
Prices $808.50
Sizes 96 t
Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL,1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.

Human RAB7B ELISA Kit - E032711 from Biobool

Category ELISA Kit

anti-RAB7 antibody [10E4] - ARG57498 from Arigo Biolaboratories

Category ELISA Kit
Search more