| Gene Symbol |
RAB7B
|
| Entrez Gene |
338382
|
| Alt Symbol |
RAB7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB7B, member RAS oncogene family
|
| Other Description |
Ras-related protein Rab-7|ras-related protein Rab-7b
|
| Swissprots |
Q96AH8
|
| Accessions |
EAW91589 EAW91590 EAW91591 Q96AH8 AI264357 AK122657 AK127140 AY094596 AAM22519 BC007382 BC017092 AAH17092 BI757251 BM671066 BX364514 DA966224 XM_006711288 XP_006711351 NM_001164522 NP_001157994 NM_001304839 NP_001291768 NM_177403 NP_796377
|
| Function |
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:20953574}.
|
| Subcellular Location |
Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
|
| Tissue Specificity |
Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte. {ECO:0000269|PubMed:15144907}.
|
| Top Pathways |
Phagosome, Amoebiasis, Salmonella infection
|