| Gene Symbol |
PHLPP2
|
| Entrez Gene |
23035
|
| Alt Symbol |
PHLPPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PH domain and leucine rich repeat protein phosphatase 2
|
| Other Description |
PH domain leucine-rich repeat-containing protein phosphatase 2
|
| Swissprots |
Q9Y2E3 Q9NV17 A1L374 Q6ZVD8
|
| Accessions |
EAW59225 EAW59226 Q6ZVD8 AB023148 BAA76775 AK001661 AK001854 BAA91943 AK124678 BAC85924 AM393067 CAL37945 AM393542 CAL38419 BC035267 AAH35267 BC129927 AAI29928 BC129983 AAI29984 BX647823 BX648157 BX648394 NM_001289003 NP_001275932 NM_015020 NP_055835
|
| Function |
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341}.
|
| Subcellular Location |
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
|
| Tissue Specificity |
In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level). {ECO:0000269|PubMed:19079341}.
|
| Top Pathways |
PI3K-Akt signaling pathway
|