PHLPP2
| Gene Symbol | PHLPP2 |
|---|---|
| Entrez Gene | 23035 |
| Alt Symbol | PHLPPL |
| Species | Human |
| Gene Type | protein-coding |
| Description | PH domain and leucine rich repeat protein phosphatase 2 |
| Other Description | PH domain leucine-rich repeat-containing protein phosphatase 2 |
| Swissprots | Q9Y2E3 Q9NV17 A1L374 Q6ZVD8 |
| Accessions | EAW59225 EAW59226 Q6ZVD8 AB023148 BAA76775 AK001661 AK001854 BAA91943 AK124678 BAC85924 AM393067 CAL37945 AM393542 CAL38419 BC035267 AAH35267 BC129927 AAI29928 BC129983 AAI29984 BX647823 BX648157 BX648394 NM_001289003 NP_001275932 NM_015020 NP_055835 |
| Function | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341}. |
| Subcellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus. |
| Tissue Specificity | In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level). {ECO:0000269|PubMed:19079341}. |
| Top Pathways | PI3K-Akt signaling pathway |
PHLPPL CRISPR/Cas9 KO Plasmid (h) - sc-411654 from Santa Cruz Biotechnology
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PHLPPL HDR Plasmid (h) - sc-411654-HDR from Santa Cruz Biotechnology
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PHLPPL Double Nickase Plasmid (h) - sc-411654-NIC from Santa Cruz Biotechnology
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PHLPPL Double Nickase Plasmid (h2) - sc-411654-NIC-2 from Santa Cruz Biotechnology
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PHLPPL CRISPR Activation Plasmid (h) - sc-411654-ACT from Santa Cruz Biotechnology
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PHLPPL CRISPR Activation Plasmid (h2) - sc-411654-ACT-2 from Santa Cruz Biotechnology
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PHLPPL Lentiviral Activation Particles (h) - sc-411654-LAC from Santa Cruz Biotechnology
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PHLPPL Lentiviral Activation Particles (h2) - sc-411654-LAC-2 from Santa Cruz Biotechnology
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PHLPPL siRNA (h) - sc-93087 from Santa Cruz Biotechnology
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PHLPPL shRNA Plasmid (h) - sc-93087-SH from Santa Cruz Biotechnology
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PHLPPL shRNA (h) Lentiviral Particles - sc-93087-V from Santa Cruz Biotechnology
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PHLPP2 RNAi - H00023035-R01 from Novus Biologicals
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MISSION® esiRNA - EHU097221 from Sigma-Aldrich
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MISSION® esiRNA - EHU100031 from Sigma-Aldrich
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MISSION® esiRNA - EHU088771 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0414 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0413 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0412 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16750 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16750 from Sigma-Aldrich
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PHLPP2 siRNA (Human) - CRH7948 from Cohesion Biosciences
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shRNA set against Human Phlpp (NM_015020.2) - SHH375000 from Creative biogene
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shRNA set against Human PHLPPL(NM_015020.2) - SHR112272 from Creative biogene
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PHLPP2 shRNA Plasmid (Human) - CHH7948 from Cohesion Biosciences
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PHLPP2 miRNA 3'UTR clone - MiUTR1H-07872 from Creative biogene
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