PHLPP2

Gene Symbol	PHLPP2
Entrez Gene	23035
Alt Symbol	PHLPPL
Species	Human
Gene Type	protein-coding
Description	PH domain and leucine rich repeat protein phosphatase 2
Other Description	PH domain leucine-rich repeat-containing protein phosphatase 2
Swissprots	Q9Y2E3 Q9NV17 A1L374 Q6ZVD8
Accessions	EAW59225 EAW59226 Q6ZVD8 AB023148 BAA76775 AK001661 AK001854 BAA91943 AK124678 BAC85924 AM393067 CAL37945 AM393542 CAL38419 BC035267 AAH35267 BC129927 AAI29928 BC129983 AAI29984 BX647823 BX648157 BX648394 NM_001289003 NP_001275932 NM_015020 NP_055835
Function	Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. {ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
Tissue Specificity	In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level). {ECO:0000269|PubMed:19079341}.
Top Pathways	PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHLPP2 protein fragment - ab125556 from Abcam Category Protein Source E. coli Species Human

PHLPP2 / PHLPPL Antibody Blocking Peptide - LS-E31328 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PHLPP2 / PHLPPL Antibody Blocking Peptide - LS-E9268 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHLPP2 / PHLPPL Antibody Blocking Peptide - LS-E26397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PHLPP2-Antibody-N-term-Blocking-Peptide - BP7799a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PHLPP2 blocking peptide - GTX89016-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PHLPP2 Peptide - AC21-1233-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PHLPP2 (C-term) Control Peptide - AP55482CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PHLPP2 Peptide - 46-180P from ProSci Category Peptide Species Human

PHLPP2 Peptide - 7021P from ProSci Category Peptide Species Human

PHLPPL fusion protein - Ag19000 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PHLPPL fusion protein - ag19198 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PHLPP2, GST-tagged - PHLPP2-7012H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human PHLPP2, His-tagged - PHLPP2-1690H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PHLPP2, GST-tagged - PHLPP2-1615H from Creative Biomart Category Protein Source E.coli Species Human

PHLPP2 protein-GST fusion - 009-001-S91 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

PHLPP2 protein-GST fusion - 009-001-S91S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human PH domain leucine-rich repeat-containing protein phosphatase 2(PHLPP2) ,partial - CSB-YP754577HU CSB-EP754577HU CSB-BP754577HU CSB-MP754577HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PHLPP2 - TP312846 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2), partial, Recombinant Protein - MBS1470497 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PHLPP2, Recombinant Protein - MBS515171 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source E.coli Species Human

PHLPP2, Peptide - MBS425064 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

PHLPP2 Recombinant Protein Antigen - NBP2-13757PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PHLPP2-Antibody-C-term-Blocking-Peptide - BP7799b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PHLPP2 Peptide, Human - M34GP11720H from Creative Peptides Category Peptide Source Synthetic. Species Human

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