| Gene Symbol |
NLRP5
|
| Entrez Gene |
126206
|
| Alt Symbol |
CLR19.8, MATER, NALP5, PAN11, PYPAF8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NLR family, pyrin domain containing 5
|
| Other Description |
NACHT, LRR and PYD domains-containing protein 5|NACHT, leucine rich repeat and PYD containing 5|mater protein homolog|maternal antigen that embryos require|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
|
| Swissprots |
Q86W29 P59047 A8MTY4
|
| Accessions |
P59047 AY054986 AAL15549 AY154460 AAO18156 BC141431 AAI41432 XM_011526444 XP_011524746 NM_153447 NP_703148
|
| Function |
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Oocyte-specific.
|
![Western Blot: NLRP5 Overexpression Lysate (Adult Normal) [NBL1-13676] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NLRP5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8190_NLRP5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13676-img0002.jpg)