Gene Symbol | NLRP5 |
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Entrez Gene | 126206 |
Alt Symbol | CLR19.8, MATER, NALP5, PAN11, PYPAF8 |
Species | Human |
Gene Type | protein-coding |
Description | NLR family, pyrin domain containing 5 |
Other Description | NACHT, LRR and PYD domains-containing protein 5|NACHT, leucine rich repeat and PYD containing 5|mater protein homolog|maternal antigen that embryos require|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5 |
Swissprots | Q86W29 P59047 A8MTY4 |
Accessions | P59047 AY054986 AAL15549 AY154460 AAO18156 BC141431 AAI41432 XM_011526444 XP_011524746 NM_153447 NP_703148 |
Function | As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}. |
Tissue Specificity | Oocyte-specific. |
NALP5 CRISPR/Cas9 KO Plasmid (h) - sc-410283 from Santa Cruz Biotechnology
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NALP5 HDR Plasmid (h) - sc-410283-HDR from Santa Cruz Biotechnology
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NALP5 Double Nickase Plasmid (h) - sc-410283-NIC from Santa Cruz Biotechnology
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NALP5 Double Nickase Plasmid (h2) - sc-410283-NIC-2 from Santa Cruz Biotechnology
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NALP5 CRISPR Activation Plasmid (h) - sc-410283-ACT from Santa Cruz Biotechnology
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NALP5 CRISPR Activation Plasmid (h2) - sc-410283-ACT-2 from Santa Cruz Biotechnology
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NALP5 Lentiviral Activation Particles (h) - sc-410283-LAC from Santa Cruz Biotechnology
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NALP5 Lentiviral Activation Particles (h2) - sc-410283-LAC-2 from Santa Cruz Biotechnology
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NALP5 siRNA (h) - sc-61145 from Santa Cruz Biotechnology
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NALP5 shRNA Plasmid (h) - sc-61145-SH from Santa Cruz Biotechnology
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NALP5 shRNA (h) Lentiviral Particles - sc-61145-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU002041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15357 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15357 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02195 from Sigma-Aldrich
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NLRP5 siRNA (Human) - CRJ4844 from Cohesion Biosciences
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shRNA set against Human Nlrp5 (NM_153447.4) - SHH353020 from Creative biogene
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shRNA set against Human NLRP5(NM_153447.4) - SHR013398 from Creative biogene
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Human NLRP5 siRNA - orb275345 from Biorbyt
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NLRP5 shRNA Plasmid (Human) - CHJ4844 from Cohesion Biosciences
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NLRP5 miRNA 3'UTR clone - MiUTR1H-06802 from Creative biogene
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