| Gene Symbol |
HCRTR1
|
| Entrez Gene |
3061
|
| Alt Symbol |
OX1R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hypocretin (orexin) receptor 1
|
| Other Description |
hypocretin receptor 1|hypocretin receptor type 1|hypocretin receptor-1|orexin receptor 1|orexin receptor type 1|orexin receptor-1|ox-1-R|ox1-R
|
| Swissprots |
O43613 A8K3A6 Q9HBV6
|
| Accessions |
AAG28020 AAL47214 AAL50221 CAC34687 EAX07600 EAX07601 EAX07602 O43613 AF041243 AAC39601 AK290521 BAF83210 BC035686 BC074796 AAH74796 CO960455 DA803650 XM_011541308 XP_011539610 NM_001525 NP_001516
|
| Function |
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|
![Western Blot: Orexin Receptor 1 Overexpression Lysate (Adult Normal) [NBL1-11473] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Orexin Receptor 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9557_Orexin%2520Receptor%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11473-img0002.jpg)