Gene Symbol | HCRTR1 |
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Entrez Gene | 3061 |
Alt Symbol | OX1R |
Species | Human |
Gene Type | protein-coding |
Description | hypocretin (orexin) receptor 1 |
Other Description | hypocretin receptor 1|hypocretin receptor type 1|hypocretin receptor-1|orexin receptor 1|orexin receptor type 1|orexin receptor-1|ox-1-R|ox1-R |
Swissprots | O43613 A8K3A6 Q9HBV6 |
Accessions | AAG28020 AAL47214 AAL50221 CAC34687 EAX07600 EAX07601 EAX07602 O43613 AF041243 AAC39601 AK290521 BAF83210 BC035686 BC074796 AAH74796 CO960455 DA803650 XM_011541308 XP_011539610 NM_001525 NP_001516 |
Function | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Neuroactive ligand-receptor interaction |
Orexin R-1 CRISPR/Cas9 KO Plasmid (h) - sc-401613 from Santa Cruz Biotechnology
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Orexin R-1 HDR Plasmid (h) - sc-401613-HDR from Santa Cruz Biotechnology
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Orexin R-1 Double Nickase Plasmid (h) - sc-401613-NIC from Santa Cruz Biotechnology
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Orexin R-1 Double Nickase Plasmid (h2) - sc-401613-NIC-2 from Santa Cruz Biotechnology
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Orexin R-1 CRISPR Activation Plasmid (h) - sc-401613-ACT from Santa Cruz Biotechnology
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Orexin R-1 CRISPR Activation Plasmid (h2) - sc-401613-ACT-2 from Santa Cruz Biotechnology
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Orexin R-1 Lentiviral Activation Particles (h) - sc-401613-LAC from Santa Cruz Biotechnology
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Orexin R-1 Lentiviral Activation Particles (h2) - sc-401613-LAC-2 from Santa Cruz Biotechnology
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Orexin R-1 siRNA (h) - sc-36131 from Santa Cruz Biotechnology
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Orexin R-1 shRNA Plasmid (h) - sc-36131-SH from Santa Cruz Biotechnology
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Orexin R-1 shRNA (h) Lentiviral Particles - sc-36131-V from Santa Cruz Biotechnology
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Orexin R1/HCRTR1 RNAi - H00003061-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9930 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9930 from Sigma-Aldrich
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HCRTR1 siRNA (Human) - CRH2083 from Cohesion Biosciences
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HCRTR1 - MBS8231919 from MyBioSource
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shRNA set against Human HCRTR1 (NM_001525.2) - SHH310897 from Creative biogene
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Human HCRTR1 siRNA - orb262585 from Biorbyt
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HCRTR1 shRNA Plasmid (Human) - CHH2083 from Cohesion Biosciences
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HCRTR1 miRNA 3'UTR clone - MiUTR4H-TG04112 from Creative biogene
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