HCRTR1

Gene Symbol HCRTR1
Entrez Gene 3061
Alt Symbol OX1R
Species Human
Gene Type protein-coding
Description hypocretin (orexin) receptor 1
Other Description hypocretin receptor 1|hypocretin receptor type 1|hypocretin receptor-1|orexin receptor 1|orexin receptor type 1|orexin receptor-1|ox-1-R|ox1-R
Swissprots O43613 A8K3A6 Q9HBV6
Accessions AAG28020 AAL47214 AAL50221 CAC34687 EAX07600 EAX07601 EAX07602 O43613 AF041243 AAC39601 AK290521 BAF83210 BC035686 BC074796 AAH74796 CO960455 DA803650 XM_011541308 XP_011539610 NM_001525 NP_001516
Function Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Top Pathways Neuroactive ligand-receptor interaction

Orexin R-1 (R-20) - sc-8073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Orexin R-1 expression in SK-N-SH (A,D), SK-N-MC (B,E) whole cell lysates and mouse brain (C,F) extract. Antibodies tested include Orexin R-1 (C-19): sc-8072 (A-C) and Orexin R-1 (R-20): sc-8073 (D-F).

Orexin R-1 (C-19) - sc-8072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Orexin R-1 expression in SK-N-SH (A,D), SK-N-MC (B,E) whole cell lysates and mouse brain (C,F) extract. Antibodies tested include Orexin R-1 (C-19): sc-8072 (A-C) and Orexin R-1 (R-20): sc-8073 (D-F).

Orexin R-1/2 (E-9) - sc-166111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Orexin R-1/2 (E-9): sc-166111. Western blot analysis of Orexin R-1/2 expression in SK-N-SH (A) and SK-N-MC (B) whole cell lysates.

Orexin R-1/2 (H-300) - sc-28936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Orexin R-1/2 (H-300): sc-28936. Western blot analysis of Orexin R-2 expression in Jurkat whole cell lysate.

Anti-Orexin Receptor 1 antibody - ab68718 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Orexin Receptor 1 antibody (ab68718) at 2 µg/ml + rat brain tissue lysate

Anti-Orexin Receptor 1 antibody - ab124199 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Orexin Receptor 1 antibody (ab124199) at 1/10 dilution + NCI-H292 cell line lysates at 35 µg

Anti-OX1R / Orexin Receptor 1 Antibody (N-Terminus) - LS-C37911 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa256-267) - LS-C73925 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody - LS-C96345 from LifeSpan Bioscience

Host Chicken
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa327-342) - LS-C122253 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (C-Terminus, Magnetic beads) - LS-C171848 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (C-Terminus, Sepharose) - LS-C171849 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa231-280) - LS-C121025 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from RAW264.7 cells, using HCRTR1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-OX1R / Orexin Receptor 1 Antibody (aa298-347) - LS-C120930 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MCF7 cells, using HCRTR1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298, AP) - LS-C258338 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa263-312) - LS-C151947 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OX1R / Orexin Receptor 1 antibody Western Blot of Human brain.

Anti-OX1R / Orexin Receptor 1 Antibody (N-Terminus) - LS-C151946 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OX1R / Orexin Receptor 1 antibody Western Blot of Fetal Brain.

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298, APC) - LS-C258339 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa358-370) - LS-C55219 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.5 ug/ml) staining of Frontal Cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298, Biotin) - LS-C258341 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298, FITC) - LS-C258343 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298, PE) - LS-C259685 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298, Azide-free, HRP) - LS-C259686 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa221-270) - LS-C292046 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OX1R / Orexin Receptor 1 Antibody (aa269-298) - LS-C329620 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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