| Gene Symbol | JUN |
|---|---|
| Entrez Gene | 3725 |
| Alt Symbol | AP-1, AP1, c-Jun |
| Species | Human |
| Gene Type | protein-coding |
| Description | jun proto-oncogene |
| Other Description | Jun activation domain binding protein|activator protein 1|enhancer-binding protein AP1|jun oncogene|p39|proto-oncogene c-Jun|transcription factor AP-1|v-jun avian sarcoma virus 17 oncogene homolog|v-jun sarcoma virus 17 oncogene homolog |
| Swissprots | Q6FHM7 Q96G93 P05412 |
| Accessions | AAA59197 AAO22993 CAM91157 EAX06628 P05412 BC002646 BC006175 AAH06175 BC009874 AAH09874 BC068522 AAH68522 BG831943 BI793062 BT019759 AAV38564 BU782554 CD370800 CR541724 CAG46525 CR541752 CAG46552 DQ896432 ABM87431 NM_002228 NP_002219 |
| Function | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646}. |
| Subcellular Location | Nucleus. |
| Top Pathways | TNF signaling pathway, Estrogen signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Oxytocin signaling pathway, Inflammatory bowel disease (IBD) |