Gene Symbol | JUN |
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Entrez Gene | 3725 |
Alt Symbol | AP-1, AP1, c-Jun |
Species | Human |
Gene Type | protein-coding |
Description | jun proto-oncogene |
Other Description | Jun activation domain binding protein|activator protein 1|enhancer-binding protein AP1|jun oncogene|p39|proto-oncogene c-Jun|transcription factor AP-1|v-jun avian sarcoma virus 17 oncogene homolog|v-jun sarcoma virus 17 oncogene homolog |
Swissprots | Q6FHM7 Q96G93 P05412 |
Accessions | AAA59197 AAO22993 CAM91157 EAX06628 P05412 BC002646 BC006175 AAH06175 BC009874 AAH09874 BC068522 AAH68522 BG831943 BI793062 BT019759 AAV38564 BU782554 CD370800 CR541724 CAG46525 CR541752 CAG46552 DQ896432 ABM87431 NM_002228 NP_002219 |
Function | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646}. |
Subcellular Location | Nucleus. |
Top Pathways | TNF signaling pathway, Estrogen signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Oxytocin signaling pathway, Inflammatory bowel disease (IBD) |
SignalSilence ® c-Jun siRNA I - 6203 from Cell Signaling Technology
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SignalSilence ® c-Jun siRNA II - 6204 from Cell Signaling Technology
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c-Jun CRISPR/Cas9 KO Plasmid (h) - sc-400077 from Santa Cruz Biotechnology
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c-Jun HDR Plasmid (h) - sc-400077-HDR from Santa Cruz Biotechnology
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c-Jun Double Nickase Plasmid (h) - sc-400077-NIC from Santa Cruz Biotechnology
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c-Jun Double Nickase Plasmid (h2) - sc-400077-NIC-2 from Santa Cruz Biotechnology
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c-Jun CRISPR Activation Plasmid (h) - sc-400077-ACT from Santa Cruz Biotechnology
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c-Jun CRISPR Activation Plasmid (h2) - sc-400077-ACT-2 from Santa Cruz Biotechnology
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c-Jun Lentiviral Activation Particles (h) - sc-400077-LAC from Santa Cruz Biotechnology
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c-Jun Lentiviral Activation Particles (h2) - sc-400077-LAC-2 from Santa Cruz Biotechnology
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c-Jun siRNA (h) - sc-29223 from Santa Cruz Biotechnology
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c-Jun shRNA Plasmid (h) - sc-29223-SH from Santa Cruz Biotechnology
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c-Jun shRNA (h) Lentiviral Particles - sc-29223-V from Santa Cruz Biotechnology
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c-Jun siRNA (h2) - sc-44201 from Santa Cruz Biotechnology
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c-Jun shRNA Plasmid (h2) - sc-44201-SH from Santa Cruz Biotechnology
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c-Jun shRNA (h2) Lentiviral Particles - sc-44201-V from Santa Cruz Biotechnology
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c-Jun siRNA (chicken) - sc-270090 from Santa Cruz Biotechnology
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c-Jun shRNA Plasmid (chicken) - sc-270090-SH from Santa Cruz Biotechnology
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c-jun RNAi - H00003725-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1032 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1032 from Sigma-Aldrich
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JUN siRNA (Human) - CRH2506 from Cohesion Biosciences
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c-Jun CRISPR/Cas9 KO Plasmid (h2) - sc-400077-KO-2 from Santa Cruz Biotechnology
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c-Jun HDR Plasmid (h2) - sc-400077-HDR-2 from Santa Cruz Biotechnology
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JUN, siRNA - MBS8227968 from MyBioSource
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