| Gene Symbol |
RAC3
|
| Entrez Gene |
5881
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
|
| Other Description |
p21-Rac3|ras-related C3 botulinum toxin substrate 3|rho family, small GTP binding protein Rac3
|
| Swissprots |
Q5U0M8 P60763
|
| Accessions |
P60763 AF008591 AAC51667 AF498966 AAM21113 BC009605 AAH09605 BC015197 AAH15197 BT019443 AAV38250 BU731383 DQ893123 ABM84049 DQ896400 ABM87399 XM_005256390 XP_005256447 NM_005052 NP_005043
|
| Function |
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}.
|
| Subcellular Location |
Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
|
| Tissue Specificity |
Highest levels in brain, also detected in heart, placenta and pancreas.
|
| Top Pathways |
Sphingolipid signaling pathway, cAMP signaling pathway, Choline metabolism in cancer, Rap1 signaling pathway, Wnt signaling pathway
|