| Gene Symbol | RAC3 |
|---|---|
| Entrez Gene | 5881 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| Other Description | p21-Rac3|ras-related C3 botulinum toxin substrate 3|rho family, small GTP binding protein Rac3 |
| Swissprots | Q5U0M8 P60763 |
| Accessions | P60763 AF008591 AAC51667 AF498966 AAM21113 BC009605 AAH09605 BC015197 AAH15197 BT019443 AAV38250 BU731383 DQ893123 ABM84049 DQ896400 ABM87399 XM_005256390 XP_005256447 NM_005052 NP_005043 |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}. |
| Subcellular Location | Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery. |
| Tissue Specificity | Highest levels in brain, also detected in heart, placenta and pancreas. |
| Top Pathways | Sphingolipid signaling pathway, cAMP signaling pathway, Choline metabolism in cancer, Rap1 signaling pathway, Wnt signaling pathway |
Rac 3 CRISPR/Cas9 KO Plasmid (h) - sc-403445 from Santa Cruz Biotechnology
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Rac 3 HDR Plasmid (h) - sc-403445-HDR from Santa Cruz Biotechnology
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Rac 3 Double Nickase Plasmid (h) - sc-403445-NIC from Santa Cruz Biotechnology
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Rac 3 Double Nickase Plasmid (h2) - sc-403445-NIC-2 from Santa Cruz Biotechnology
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Rac 3 CRISPR Activation Plasmid (h) - sc-403445-ACT from Santa Cruz Biotechnology
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Rac 3 CRISPR Activation Plasmid (h2) - sc-403445-ACT-2 from Santa Cruz Biotechnology
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Rac 3 Lentiviral Activation Particles (h) - sc-403445-LAC from Santa Cruz Biotechnology
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Rac 3 Lentiviral Activation Particles (h2) - sc-403445-LAC-2 from Santa Cruz Biotechnology
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Rac 3 siRNA (h) - sc-41840 from Santa Cruz Biotechnology
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Rac 3 shRNA Plasmid (h) - sc-41840-SH from Santa Cruz Biotechnology
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Rac 3 shRNA (h) Lentiviral Particles - sc-41840-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN17887 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17887 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03527 from Sigma-Aldrich
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RAC3 siRNA (Human) - CRH3971 from Cohesion Biosciences
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RAC3 - MBS8206629 from MyBioSource
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shRNA set against Human RAC3 (NM_005052.2) - SHH388856 from Creative biogene
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shRNA set against Human RAC3(NM_005052.2) - SHR161250 from Creative biogene
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Human RAC3 siRNA - orb264473 from Biorbyt
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RAC3 shRNA Plasmid (Human) - CHH3971 from Cohesion Biosciences
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RAC3 miRNA 3'UTR clone - MiUTR1H-08590 from Creative biogene
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