Gene Symbol | PRPF6 |
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Entrez Gene | 24148 |
Alt Symbol | ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6 |
Species | Human |
Gene Type | protein-coding |
Description | pre-mRNA processing factor 6 |
Other Description | PRP6 homolog|PRP6 pre-mRNA processing factor 6 homolog|U5 snRNP-associated 102 kDa protein|U5-102 kDa protein|androgen receptor N-terminal domain transactivating protein-1|androgen receptor N-terminal domain-transactivating protein 1|p102 U5 small nuclear ribonucleoprotein particle-binding protein|pre-mRNA-processing factor 6|putative mitochondrial outer membrane protein import receptor |
Swissprots | Q5VXS5 Q9NTE6 Q9H4U8 B2RAR5 O95109 Q9H4T9 Q9H3Z1 B3KMC6 O94906 |
Accessions | CAH05536 EAW75174 EAW75175 EAW75176 EAW75177 EAW75178 EAW75179 O94906 AB019219 BAA37140 AF026031 AAD01798 AF221842 AAF66128 AK001554 BAG50938 AK225993 AK314310 BAG36962 AL137320 CAB70695 BC001666 AAH01666 BI562505 BP366197 XM_006723769 XP_006723832 NM_012469 NP_036601 |
Function | Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962}. |
Subcellular Location | Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12039962}. |
Top Pathways | Spliceosome |
PRP6 (B-1) - sc-166889 from Santa Cruz Biotechnology
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PRP6 (C-12) - sc-271882 from Santa Cruz Biotechnology
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PRP6 (D-3) - sc-271866 from Santa Cruz Biotechnology
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PRP6 (D-4) - sc-166890 from Santa Cruz Biotechnology
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PRP6 (H-300) - sc-48786 from Santa Cruz Biotechnology
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PRP6 (N-20) - sc-13253 from Santa Cruz Biotechnology
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PRP6 (P-17) - sc-13254 from Santa Cruz Biotechnology
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Anti-C20orf14 antibody - ab68627 from Abcam
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Anti-PRP6 antibody - ab124229 from Abcam
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Anti-PRPF6 / TOM Antibody (aa806-827, APC) - LS-C239489 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa806-827, AP) - LS-C239488 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa806-827, FITC) - LS-C239491 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa806-827, Biotin) - LS-C239490 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa806-827, PE) - LS-C239493 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa806-827, Azide-free, HRP) - LS-C248561 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa806-827) - LS-C324315 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa747-796) - LS-C199496 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa51-100) - LS-C40320 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa851-900) - LS-C40319 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa807-836) - LS-C162176 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa1-50) - LS-C289487 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody - LS-C334958 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa150-200) - LS-C289488 from LifeSpan Bioscience
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Anti-PRPF6 / TOM Antibody (aa196-229) - LS-C344387 from LifeSpan Bioscience
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PRPF6 Antibody - NBP1-46212 from Novus Biologicals
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