| Gene Symbol |
PRPF6
|
| Entrez Gene |
24148
|
| Alt Symbol |
ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pre-mRNA processing factor 6
|
| Other Description |
PRP6 homolog|PRP6 pre-mRNA processing factor 6 homolog|U5 snRNP-associated 102 kDa protein|U5-102 kDa protein|androgen receptor N-terminal domain transactivating protein-1|androgen receptor N-terminal domain-transactivating protein 1|p102 U5 small nuclear ribonucleoprotein particle-binding protein|pre-mRNA-processing factor 6|putative mitochondrial outer membrane protein import receptor
|
| Swissprots |
Q5VXS5 Q9NTE6 Q9H4U8 B2RAR5 O95109 Q9H4T9 Q9H3Z1 B3KMC6 O94906
|
| Accessions |
CAH05536 EAW75174 EAW75175 EAW75176 EAW75177 EAW75178 EAW75179 O94906 AB019219 BAA37140 AF026031 AAD01798 AF221842 AAF66128 AK001554 BAG50938 AK225993 AK314310 BAG36962 AL137320 CAB70695 BC001666 AAH01666 BI562505 BP366197 XM_006723769 XP_006723832 NM_012469 NP_036601
|
| Function |
Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000269|PubMed:12039962}.
|
| Subcellular Location |
Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12039962}.
|
| Top Pathways |
Spliceosome
|
![Western Blot: PRPF6 Overexpression Lysate (Adult Normal) [NBL1-14824] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRPF6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8072_PRPF6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14824-img0002.jpg)