| Gene Symbol |
FEZ1
|
| Entrez Gene |
9638
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fasciculation and elongation protein zeta 1 (zygin I)
|
| Other Description |
fasciculation and elongation protein zeta-1|zygin I|zygin-1
|
| Swissprots |
O00728 Q6IBI7 Q99689 O00679
|
| Accessions |
EAW67636 EAW67637 EAW67638 EAW67639 Q99689 AK296554 BAG59177 BC009545 AAH09545 BM663785 CN310685 CR456817 CAG33098 CR541954 CAG46752 DA697171 DQ890963 ABM81889 DQ894135 ABM85061 U60060 AAC51282 U60062 AAC51284 U69139 AAB40660 XM_005271734 XP_005271791 XM_005271735 XP_005271792 XM_011543071 XP_011541373 NM_005103 NP_005094 NM_022549 NP_072043
|
| Function |
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18439996}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Mainly expressed in brain.
|