ARRB1

Gene Symbol	ARRB1
Entrez Gene	408
Alt Symbol	ARB1, ARR1
Species	Human
Gene Type	protein-coding
Description	arrestin, beta 1
Other Description	arrestin 2|beta-arrestin-1
Swissprots	Q9BTK8 B6V9G8 O75630 P49407 Q2PP20 O75625
Accessions	ABC40724 EAW74960 EAW74961 EAW74962 P49407 AF084040 AAC33295 AF084940 AAC34123 AK074660 AK289718 BAF82407 AK293758 BAH11589 AL157484 BC003636 AAH03636 BM681392 BQ883950 BU594296 BX402200 CB853136 CD365891 CR735690 DA358665 FJ348262 ACI96306 HQ447288 ADQ31775 L04685 AAA35558 XM_005273997 XP_005274054 XM_011545034 XP_011543336 XM_011545035 XP_011543337 XM_011545036 XP_011543338 NM_004041 NP_004032 NM_020251 NP_064647
Function	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.
Top Pathways	MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospho-ARRB1 / Beta Arrestin 1 (Ser412) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1153 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Human ARRB1 / Beta Arrestin 1 ELISA Kit (Cell-Based ELISA) - LS-F1805 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse ARRB1 / Beta Arrestin 1 ELISA Kit (Sandwich ELISA) - LS-F9785 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Arrestin Beta 1, ARRb1, Human, ELISA Kit - E-EL-H0502 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Beta-arrestin-1, ARRB1, Human, ELISA Kit - E1993h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Arrestin Beta 1, ARRb1, Rabbit, ELISA Kit - E-EL-RB1126 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arrestin Beta 1, ARRb1, Chicken, ELISA Kit - E-EL-Ch0624 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Arrestin Beta 1, ARRb1, Porcine, ELISA Kit - E-EL-P0439 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arrestin Beta 1, ARRb1, Monkey, ELISA Kit - E-EL-MK0420 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human ARRb1 ELISA Kit - HA0351 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine ARRb1 ELISA Kit - AA0351 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

arrestin, beta 1, ELISA Kit - MBS9334094 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.25 ng/ml - 8 ng/ml.

Arrestin 1 Colorimetric Cell-Based ELISA Kit - CB5049 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Arrestin 1 (Phospho-Ser412) Colorimetric Cell-Based ELISA Kit - CBP1138 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Arrestin Beta 1, ELISA Kit - MBS744453 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Arrestin Beta 1, ELISA Kit - MBS750355 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS747033 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS008230 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS047657 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS724010 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS016953 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 pg/ml. Range 31.2 pg/ml - 1000 pg/ml.

Arrestin Beta 1, ELISA Kit - MBS015174 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS755031 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS104023 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arrestin Beta 1, ELISA Kit - MBS746072 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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