ARRB1

Gene Symbol	ARRB1
Entrez Gene	408
Alt Symbol	ARB1, ARR1
Species	Human
Gene Type	protein-coding
Description	arrestin, beta 1
Other Description	arrestin 2|beta-arrestin-1
Swissprots	Q9BTK8 B6V9G8 O75630 P49407 Q2PP20 O75625
Accessions	ABC40724 EAW74960 EAW74961 EAW74962 P49407 AF084040 AAC33295 AF084940 AAC34123 AK074660 AK289718 BAF82407 AK293758 BAH11589 AL157484 BC003636 AAH03636 BM681392 BQ883950 BU594296 BX402200 CB853136 CD365891 CR735690 DA358665 FJ348262 ACI96306 HQ447288 ADQ31775 L04685 AAA35558 XM_005273997 XP_005274054 XM_011545034 XP_011543336 XM_011545035 XP_011543337 XM_011545036 XP_011543338 NM_004041 NP_004032 NM_020251 NP_064647
Function	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.
Top Pathways	MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® β-Arrestin 1 siRNA I - 6218 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

β-Arrestin-1 siRNA (h) - sc-29741 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

β-Arrestin-1 shRNA Plasmid (h) - sc-29741-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

β-Arrestin-1 shRNA (h) Lentiviral Particles - sc-29741-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU084091 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3537 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3537 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05948 from Sigma-Aldrich Category miRNA

ARRB1 siRNA (Human) - CRH0296 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ARRB1 - MBS8209500 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ARRB1 (NM_004041.4) - SHH240750 from Creative biogene Category siRNA Species Reactivities Human

Human ARRB1 siRNA - orb260798 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ARRB1 shRNA Plasmid (Human) - CHH0296 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ARRB1 miRNA 3'UTR clone - MiUTR3H-00194 from Creative biogene Species Reactivities Human

ARRB1 miRNA 3'UTR clone - MiUTR3H-00195 from Creative biogene Species Reactivities Human

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