ARRB1

Gene Symbol	ARRB1
Entrez Gene	408
Alt Symbol	ARB1, ARR1
Species	Human
Gene Type	protein-coding
Description	arrestin, beta 1
Other Description	arrestin 2|beta-arrestin-1
Swissprots	Q9BTK8 B6V9G8 O75630 P49407 Q2PP20 O75625
Accessions	ABC40724 EAW74960 EAW74961 EAW74962 P49407 AF084040 AAC33295 AF084940 AAC34123 AK074660 AK289718 BAF82407 AK293758 BAH11589 AL157484 BC003636 AAH03636 BM681392 BQ883950 BU594296 BX402200 CB853136 CD365891 CR735690 DA358665 FJ348262 ACI96306 HQ447288 ADQ31775 L04685 AAA35558 XM_005273997 XP_005274054 XM_011545034 XP_011543336 XM_011545035 XP_011543337 XM_011545036 XP_011543338 NM_004041 NP_004032 NM_020251 NP_064647
Function	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.
Top Pathways	MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human beta Arrestin 1 full length protein - ab114604 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human beta Arrestin 1 full length protein - ab151827 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

Human beta Arrestin 1 peptide - ab31866 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human beta Arrestin 1 peptide - ab31867 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human beta Arrestin 1 protein fragment - ab114605 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human pan Arrestin peptide - ab4932 from Abcam Category Peptide Species Human

ARRB1 / Beta Arrestin 1 Antibody Blocking Peptide - LS-E1361 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARRB1 / Beta Arrestin 1 Antibody Blocking Peptide - LS-E10621 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human beta-Arrestin 1 Protein - H00000408-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human beta-Arrestin 1 Protein - H00000408-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARRB1-Antibody-C-term-Blocking-peptide - BP12005b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ARRB1 protein - orb49761 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

ARRB1 peptide - orb218998 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit, Monkey

Beta-arrestin-1 (phospho-Ser412) Blocking Peptide - abx062272 from Abbexa Category Peptide Species Human, Mouse, Rat

Beta-arrestin-1 Blocking Peptide - abx062029 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Rabbit

Human Arrestin Beta 1 Protein - abx065459 from Abbexa Category Protein Source E.coli Species Human

Arrestin beta-1 / ARRB1 - H00000408-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Arrestin beta-1 / ARRB1 - H00000408-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Arrestin beta-1 / ARRB1 - H00000408-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Arrestin beta-1 / ARRB1 - H00000408-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

beta-Arrestin 1, ARRB1, Human, Recombinant - 19-C102 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

Arrestin fusion protein - ag7504 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Arrestin fusion protein - Ag7608 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Beta-arrestin 1/2 Peptide - 300120 from ABBIOTEC Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ARRB1 Protein - BP001229-C102 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

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