| Gene Symbol |
ROS1
|
| Entrez Gene |
6098
|
| Alt Symbol |
MCF3, ROS, c-ros-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ROS proto-oncogene 1 , receptor tyrosine kinase
|
| Other Description |
c-ros oncogene 1 , receptor tyrosine kinase|proto-oncogene c-Ros-1|proto-oncogene tyrosine-protein kinase ROS|transmembrane tyrosine-specific protein kinase|v-ros avian UR2 sarcoma virus oncogene homolog 1
|
| Swissprots |
Q15368 P08922 Q5TDB5
|
| Accessions |
AAA60277 EAW48208 EAW48209 P08922 BC144556 BC166687 AAI66687 M13880 AAA36580 M34353 AAA60278 XM_006715548 XP_006715611 XM_011536049 XP_011534351 XM_011536050 XP_011534352 XM_011536051 XP_011534353 XM_011536052 XP_011534354 XM_011536053 XP_011534355 XM_011536054 XP_011534356 XM_011536055 XP_011534357 XM_011536056 XP_011534358 XM_011536057 XP_011534359 XM_011536058 XP_011534360 NM_002944 NP_002935
|
| Function |
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in brain. Expression is increased in primary gliomas. {ECO:0000269|PubMed:8143271}.
|