ROS1

Gene Symbol ROS1
Entrez Gene 6098
Alt Symbol MCF3, ROS, c-ros-1
Species Human
Gene Type protein-coding
Description ROS proto-oncogene 1 , receptor tyrosine kinase
Other Description c-ros oncogene 1 , receptor tyrosine kinase|proto-oncogene c-Ros-1|proto-oncogene tyrosine-protein kinase ROS|transmembrane tyrosine-specific protein kinase|v-ros avian UR2 sarcoma virus oncogene homolog 1
Swissprots Q15368 P08922 Q5TDB5
Accessions AAA60277 EAW48208 EAW48209 P08922 BC144556 BC166687 AAI66687 M13880 AAA36580 M34353 AAA60278 XM_006715548 XP_006715611 XM_011536049 XP_011534351 XM_011536050 XP_011534352 XM_011536051 XP_011534353 XM_011536052 XP_011534354 XM_011536053 XP_011534355 XM_011536054 XP_011534356 XM_011536055 XP_011534357 XM_011536056 XP_011534358 XM_011536057 XP_011534359 XM_011536058 XP_011534360 NM_002944 NP_002935
Function Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
Subcellular Location Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Expressed in brain. Expression is increased in primary gliomas. {ECO:0000269|PubMed:8143271}.

Ros CRISPR/Cas9 KO Plasmid (h) - sc-402450 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros HDR Plasmid (h) - sc-402450-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros Double Nickase Plasmid (h) - sc-402450-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros Double Nickase Plasmid (h2) - sc-402450-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros CRISPR Activation Plasmid (h) - sc-402450-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros CRISPR Activation Plasmid (h2) - sc-402450-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros Lentiviral Activation Particles (h) - sc-402450-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros Lentiviral Activation Particles (h2) - sc-402450-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ros siRNA (h) - sc-40087 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ros shRNA Plasmid (h) - sc-40087-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ros shRNA (h) Lentiviral Particles - sc-40087-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ROS RNAi - H00006098-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU021521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1997 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1995 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1996 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1561 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1561 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ROS1 siRNA (Human) - CRH4106 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ROS1 - MBS828048 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ROS1(NM_002944.2) - SHR190122 from Creative biogene

Category siRNA
Species Reactivities Human

Human ROS1 siRNA - orb264608 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ROS1 shRNA Plasmid (Human) - CHH4106 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ROS1 miRNA 3'UTR clone - MiUTR1H-08926 from Creative biogene

Species Reactivities Human
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