ROS1

Gene Symbol	ROS1
Entrez Gene	6098
Alt Symbol	MCF3, ROS, c-ros-1
Species	Human
Gene Type	protein-coding
Description	ROS proto-oncogene 1 , receptor tyrosine kinase
Other Description	c-ros oncogene 1 , receptor tyrosine kinase|proto-oncogene c-Ros-1|proto-oncogene tyrosine-protein kinase ROS|transmembrane tyrosine-specific protein kinase|v-ros avian UR2 sarcoma virus oncogene homolog 1
Swissprots	Q15368 P08922 Q5TDB5
Accessions	AAA60277 EAW48208 EAW48209 P08922 BC144556 BC166687 AAI66687 M13880 AAA36580 M34353 AAA60278 XM_006715548 XP_006715611 XM_011536049 XP_011534351 XM_011536050 XP_011534352 XM_011536051 XP_011534353 XM_011536052 XP_011534354 XM_011536053 XP_011534355 XM_011536054 XP_011534356 XM_011536055 XP_011534357 XM_011536056 XP_011534358 XM_011536057 XP_011534359 XM_011536058 XP_011534360 NM_002944 NP_002935
Function	Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in brain. Expression is increased in primary gliomas. {ECO:0000269|PubMed:8143271}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ROS1 (D4D6 ® ) Rabbit mAb (Biotinylated) - 12368 from Cell Signaling Technology Prices $299.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal

Phospho-ROS1 (Tyr2274) Antibody - 3078 from Cell Signaling Technology Prices $287.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

ROS1 (D4D6 ® ) Rabbit mAb - 3287 from Cell Signaling Technology Prices $129.00, $397.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal

ROS1 (69D6) Mouse mAb - 3266 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 69D6

Ros (C-20) - sc-6347 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Ros (H-300) - sc-28974 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Ros (W-22) - sc-130869 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-ROS (phospho Y2114) antibody - ab191522 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROS antibody - ab5512 from Abcam Prices $390.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ROS antibody [4-6G] - ab108492 from Abcam Prices $384.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4-6G

Anti-ROS antibody [4-6G] (Biotin) - ab129379 from Abcam Prices $373.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4-6G

Anti-ROS antibody [EPMGHR2] - ab189925 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPMGHR2

Anti-ROS antibody [EPR9625] - ab181113 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9625

Anti-ROS antibody - C-terminal - ab200113 from Abcam Host Rabbit Clonality Polyclonal

Anti-ROS antibody - C-terminal - ab174674 from Abcam Prices $370.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63, AP) - LS-C282395 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa2307-2318) - LS-C186598 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63, APC) - LS-C282397 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63, Biotin) - LS-C282398 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63, FITC) - LS-C282399 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63, Azide-free, HRP) - LS-C282400 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63) - LS-C328570 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa33-63, PE) - LS-C282401 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ROS1 / ROS Antibody (aa2126-2347, clone 4G7) - LS-C339697 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4G7

Anti-ROS1 / ROS Antibody (aa2126-2347, clone 4H7) - LS-C339701 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4H7

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