| Gene Symbol |
DAPP1
|
| Entrez Gene |
27071
|
| Alt Symbol |
BAM32
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual adaptor of phosphotyrosine and 3-phosphoinositides
|
| Other Description |
B-cell adapter molecule of 32 kDa|b lymphocyte adapter protein Bam32|dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide|hDAPP1
|
| Swissprots |
Q9UHF2 Q9UN19 Q8TCK5
|
| Accessions |
EAX06108 EAX06109 EAX06110 EAX06111 Q9UN19 AF161551 AAF29038 AF163254 AAD49697 AF178987 AAF44351 AF186022 AAF14578 AK301355 BAG62900 AL713793 CAD28547 BC012924 AAH12924 BM968883 CA428013 DN995752 DQ893576 ABM84502 DQ894665 ABM85591 XM_011531840 XP_011530142 XM_011531841 XP_011530143 XM_011531842 XP_011530144 XM_011531843 XP_011530145 XR_938719 NM_001306151 NP_001293080 NM_014395 NP_055210
|
| Function |
May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10770799}. Membrane {ECO:0000269|PubMed:10770799}; Peripheral membrane protein {ECO:0000269|PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation.
|
| Tissue Specificity |
Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. {ECO:0000269|PubMed:10432293}.
|
| Top Pathways |
B cell receptor signaling pathway
|
![Western Blot: DAPP1 Overexpression Lysate (Adult Normal) [NBL1-09718] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DAPP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5000_DAPP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09718-img0002.jpg)