DAPP1

Gene Symbol DAPP1
Entrez Gene 27071
Alt Symbol BAM32
Species Human
Gene Type protein-coding
Description dual adaptor of phosphotyrosine and 3-phosphoinositides
Other Description B-cell adapter molecule of 32 kDa|b lymphocyte adapter protein Bam32|dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide|hDAPP1
Swissprots Q9UHF2 Q9UN19 Q8TCK5
Accessions EAX06108 EAX06109 EAX06110 EAX06111 Q9UN19 AF161551 AAF29038 AF163254 AAD49697 AF178987 AAF44351 AF186022 AAF14578 AK301355 BAG62900 AL713793 CAD28547 BC012924 AAH12924 BM968883 CA428013 DN995752 DQ893576 ABM84502 DQ894665 ABM85591 XM_011531840 XP_011530142 XM_011531841 XP_011530143 XM_011531842 XP_011530144 XM_011531843 XP_011530145 XR_938719 NM_001306151 NP_001293080 NM_014395 NP_055210
Function May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10770799}. Membrane {ECO:0000269|PubMed:10770799}; Peripheral membrane protein {ECO:0000269|PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation.
Tissue Specificity Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. {ECO:0000269|PubMed:10432293}.
Top Pathways B cell receptor signaling pathway

Phospho-DAPP1/BAM32 (Tyr139) (D7G4G) Rabbit mAb - 13703 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7G4G
Western blot analysis of extracts from Daudi and Ramos cells, untreated (-) or treated with anti-IgM (12 μg/ml, 10 min; +), using Phospho-DAPP1/BAM32 (Tyr139) (D7G4G) Rabbit mAb (upper), DAPP1/BAM32 (D9K4O) Rabbit mAb #13598 (middle), and β-Actin (D6A8) Rabbit mAb #8457 (lower).

DAPP1/BAM32 (D9K4O) Rabbit mAb - 13598 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9K4O
Western blot analysis of extracts from various cell lines using DAPP1/BAM32 (D9K4O) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Bam32 Antibody - 3802 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

BAM32 (FL-280) - sc-67166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BAM32 (FL-280): sc-67166. Western blot analysis of BAM32 expression in non-transfected: sc-117752 (A) and human BAM32 transfected: sc-113815 (B) 293T whole cell lysates.

BAM32 (E-10) - sc-133166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BAM32 (E-10): sc-133166. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bone marrow tissue showing cytoplasmic staining of subset of hematopoietic cells.

BAM32 (C-13) - sc-46789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

BAM32 (4H9) - sc-130559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BAM32 (4H9): sc-130559. Western blot analysis of BAM32 expression in non-transfected: sc-117752 (A) and human BAM32 transfected: sc-174819 (B) 293T whole cell lysates.

BAM32 (UW32) - sc-73653 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BAM32 (UW32): sc-73653. Western blot analysis of BAM32 expression in U-698-M (A) and JEG-3 (B) whole cell lysates.

Anti-DAPP1 (phospho Y139) antibody - ab63396 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab63396, at 1/500 dilution, staining DAPP1 in A549 cells by Immunofluorescence, in the absence (left image) or presence (right image) of the immunising peptide.

Anti-DAPP1 antibody - ab63349 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DAPP1 antibody (ab63349) at 1/500 dilutionLane 1 : extracts from 293 cells, treated with Insulin (0.01U/ml, 2mins), without immunising peptideLane 2 : extracts from 293 cells, treated with Insulin (0.01U/ml, 2mins), with immunising peptide

Anti-DAPP1 antibody - ab123498 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Lane 1 : Anti-DAPP1 antibody (ab123498) at 0.1 µg/mlLane 2 : Anti-DAPP1 antibody (ab123498) at 1 mg/mlLane 3 : Anti-DYKDDDDK Tag antibody at 1/3000 dilutionLane 1 : HEK293 lysate in RIPA buffer over expressing Human DAPP1 with DYKDDDDK tag Lane 2 : Mock-transfected HEK293 Lane 3 : HEK293 lysate in RIPA buffer over expressing Human DAPP1 with DYKDDDDK tag

Anti-DAPP1 antibody - ab167294 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DAPP1 antibody (ab167294) at 1 µg/mlLane 1 : DAPP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-DAPP1 antibody - ab49926 from Abcam

Host Chicken
Clonality Polyclonal

Anti-DAPP1 antibody [EPR4993(2)] - ab131212 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4993(2)
All lanes : Anti-DAPP1 antibody [EPR4993(2)] (ab131212) at 1/1000 dilutionLane 1 : Ramos cell lysateLane 2 : IM-9 cell lysateLysates/proteins at 10 µg per lane.

Anti-DAPP1 / BAM32 Antibody (aa267-280) - LS-C112746 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa247-275, AP) - LS-C234416 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa247-275, APC) - LS-C234417 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa247-275, Biotin) - LS-C234418 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa247-275, FITC) - LS-C234419 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa247-275, PE) - LS-C246828 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa105-154) - LS-C117878 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from 293 cells, treated with Insulin 0.01U/ml 2', using DAPP1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-DAPP1 / BAM32 Antibody (aa247-275, Azide-free, HRP) - LS-C249794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody - LS-C307171 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa246-275) - LS-C320741 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAPP1 / BAM32 Antibody (aa107-156) - LS-C111593 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DAPP1 antibody LS-C111593 Western blot of PANC1 cell lysate.
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