Gene Symbol | SMARCD1 |
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Entrez Gene | 6602 |
Alt Symbol | BAF60A, CRACD1, Rsc6p |
Species | Human |
Gene Type | protein-coding |
Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 |
Other Description | 60 kDa BRG-1/Brm-associated factor subunit A|BRG1-associated factor 60A|SWI/SNF complex 60 kDa subunit A|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1|Swp73-like protein|chromatin remodeling complex BAF60A subunit|mammalian chromatin remodeling complex BRG1-associated factor 60A |
Swissprots | Q9Y635 Q96GM5 Q92924 A6NN27 |
Accessions | EAW58120 EAW58121 EAW58122 EAW58123 EAW58124 EAW58125 EAW58126 EAW58127 Q96GM5 AA610093 AF109733 AAD23390 AK130517 AK292700 BAF85389 AK293932 BAG57311 BC000063 BC009368 AAH09368 BE905082 CN272379 DA825057 DB010252 EU447009 ABZ92538 N75126 U66617 AAC50695 XM_005269107 XP_005269164 XM_011538695 XP_011536997 XR_944683 XR_944684 NM_003076 NP_003067 NM_139071 NP_620710 |
Function | Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essent |
Subcellular Location | Nucleus {ECO:0000269|PubMed:8804307, ECO:0000305}. |
Tissue Specificity | Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta. {ECO:0000269|PubMed:8804307}. |
BAF60a (A-11) - sc-514400 from Santa Cruz Biotechnology
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BAF60a (23) - sc-135843 from Santa Cruz Biotechnology
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BAF60a (G-13) - sc-82778 from Santa Cruz Biotechnology
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Anti-SMARCD1 antibody - ab86029 from Abcam
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Anti-SMARCD1 antibody - ab123788 from Abcam
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Anti-SMARCD1 / BAF60A Antibody (aa431-459, AP) - LS-C217608 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa431-459, APC) - LS-C217609 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa431-459, Biotin) - LS-C217610 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa431-459, Azide-free, HRP) - LS-C217613 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa431-459, FITC) - LS-C217614 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa431-459, PE) - LS-C217615 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335, AP) - LS-C217616 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335, APC) - LS-C217617 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa180-229) - LS-C102766 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335, Biotin) - LS-C217618 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335, FITC) - LS-C217619 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335, Azide-free, HRP) - LS-C217620 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa1-50) - LS-C288386 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335, PE) - LS-C217621 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa250-300) - LS-C288389 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa430-460) - LS-C325198 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335) - LS-C325199 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa309-335) - LS-C157935 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody (aa431-459) - LS-C161308 from LifeSpan Bioscience
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Anti-SMARCD1 / BAF60A Antibody - LS-C332030 from LifeSpan Bioscience
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