SIK1
| Gene Symbol | SIK1 |
|---|---|
| Entrez Gene | 150094 |
| Alt Symbol | MSK, SIK, SNF1LK |
| Species | Human |
| Gene Type | protein-coding |
| Description | salt-inducible kinase 1 |
| Other Description | SIK-1|SNF1-like kinase|myocardial SNF1-like kinase|salt-inducible protein kinase 1|serine/threonine protein kinase|serine/threonine-protein kinase SIK1|serine/threonine-protein kinase SNF1-like kinase 1|serine/threonine-protein kinase SNF1LK |
| Swissprots | A6NC84 Q6ZNL8 Q86YJ2 P57059 Q5R2V5 |
| Accessions | BAA95536 EAX09495 EAX09496 P57059 AB047786 BAD74070 AI073528 AK131076 BAC85126 BC038504 AAH38504 BM840872 CF528907 DQ892466 ABM83392 DQ895679 ABM86605 XM_011529474 XP_011527776 NM_173354 NP_775490 |
| Function | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expressi |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16306228}. Nucleus {ECO:0000269|PubMed:16306228}. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ. |
| Top Pathways | Glucagon signaling pathway |
SIK1 (Y-20) - sc-83754 from Santa Cruz Biotechnology
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SIK1 (H-40) - sc-366014 from Santa Cruz Biotechnology
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SIK1 (E-22) - sc-134002 from Santa Cruz Biotechnology
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Anti-Snf1lk antibody - ab64428 from Abcam
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Anti-Snf1lk antibody - ab118317 from Abcam
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Anti-Snf1lk antibody - ab200224 from Abcam
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Anti-Snf1lk antibody - ab168263 from Abcam
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Anti-Snf1lk antibody - ab133785 from Abcam
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Anti-Snf1lk antibody - C-terminal - ab173892 from Abcam
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Anti-SIK1 / MSK Antibody (aa572-600, AP) - LS-C217502 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa572-600, APC) - LS-C217503 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa572-600, Biotin) - LS-C217504 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa572-600, FITC) - LS-C217505 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa572-600, Azide-free, HRP) - LS-C217506 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa572-600, PE) - LS-C217507 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus, AP) - LS-C220660 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus, APC) - LS-C220662 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus, FITC) - LS-C220664 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa551-600) - LS-C145212 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus, Biotin) - LS-C220663 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus, Azide-free, HRP) - LS-C220665 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus, PE) - LS-C220666 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (C-Terminus) - LS-C328672 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (aa572-600) - LS-C330134 from LifeSpan Bioscience
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Anti-SIK1 / MSK Antibody (N-Terminus) - LS-C80785 from LifeSpan Bioscience
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