SIK1

Gene Symbol	SIK1
Entrez Gene	150094
Alt Symbol	MSK, SIK, SNF1LK
Species	Human
Gene Type	protein-coding
Description	salt-inducible kinase 1
Other Description	SIK-1|SNF1-like kinase|myocardial SNF1-like kinase|salt-inducible protein kinase 1|serine/threonine protein kinase|serine/threonine-protein kinase SIK1|serine/threonine-protein kinase SNF1-like kinase 1|serine/threonine-protein kinase SNF1LK
Swissprots	A6NC84 Q6ZNL8 Q86YJ2 P57059 Q5R2V5
Accessions	BAA95536 EAX09495 EAX09496 P57059 AB047786 BAD74070 AI073528 AK131076 BAC85126 BC038504 AAH38504 BM840872 CF528907 DQ892466 ABM83392 DQ895679 ABM86605 XM_011529474 XP_011527776 NM_173354 NP_775490
Function	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expressi
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16306228}. Nucleus {ECO:0000269|PubMed:16306228}. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.
Top Pathways	Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Snf1lk protein fragment - ab195112 from Abcam Category Protein Prices $345.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Snf1lk full length protein - ab165600 from Abcam Category Protein Source Wheat germ Species Human

Human Snf1lk protein fragment - ab165601 from Abcam Category Protein Source Wheat germ Species Human

SIK1 / MSK Antibody Blocking Peptide - LS-E5696 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIK1 / MSK Antibody Blocking Peptide - LS-E16749 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIK1 / MSK Antibody Blocking Peptide - LS-E9494 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIK1 / MSK Antibody Blocking Peptide - LS-E31113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human SIK1/Snf1lk Protein - H00150094-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SIK1/Snf1lk Protein - H00150094-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

SIK1/Snf1lk Blocking Peptide - NBP1-76571PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SIK1/Snf1lk Peptide - P3104 from Novus Biologicals Category Peptide Species Human

SNF1LK-Antibody-C-term-Blocking-Peptide - BP8099b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Sik1 Blocking Peptide - 33R-9237 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SNF1LK Blocking Peptide - 33R-6587 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIK1 - H00150094-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SIK1 - H00150094-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SIK1 - H00150094-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SIK1 - P5639 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

SIK1 control peptide - AP26137CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SIK1 Peptide - 6299P from ProSci Category Peptide Species Human

SIK1 fusion protein - Ag10954 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

SIK1 fusion protein - ag10984 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Salt-inducible Kinase 1, His-tagged, Active - SIK1-431H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human SIK, GST-tagged - SIK1-48H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

SIK Protein, active, 250 µg - 14-652M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-652) and in bulk (cat# 14-652-K) Source Expressed by baculovirus in Sf21 insect cells.

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