SIK1
| Gene Symbol | SIK1 |
|---|---|
| Entrez Gene | 150094 |
| Alt Symbol | MSK, SIK, SNF1LK |
| Species | Human |
| Gene Type | protein-coding |
| Description | salt-inducible kinase 1 |
| Other Description | SIK-1|SNF1-like kinase|myocardial SNF1-like kinase|salt-inducible protein kinase 1|serine/threonine protein kinase|serine/threonine-protein kinase SIK1|serine/threonine-protein kinase SNF1-like kinase 1|serine/threonine-protein kinase SNF1LK |
| Swissprots | A6NC84 Q6ZNL8 Q86YJ2 P57059 Q5R2V5 |
| Accessions | BAA95536 EAX09495 EAX09496 P57059 AB047786 BAD74070 AI073528 AK131076 BAC85126 BC038504 AAH38504 BM840872 CF528907 DQ892466 ABM83392 DQ895679 ABM86605 XM_011529474 XP_011527776 NM_173354 NP_775490 |
| Function | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expressi |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16306228}. Nucleus {ECO:0000269|PubMed:16306228}. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ. |
| Top Pathways | Glucagon signaling pathway |
SIK1 CRISPR/Cas9 KO Plasmid (h) - sc-401769 from Santa Cruz Biotechnology
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SIK1 HDR Plasmid (h) - sc-401769-HDR from Santa Cruz Biotechnology
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SIK1 Double Nickase Plasmid (h) - sc-401769-NIC from Santa Cruz Biotechnology
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SIK1 Double Nickase Plasmid (h2) - sc-401769-NIC-2 from Santa Cruz Biotechnology
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SIK1 CRISPR Activation Plasmid (h) - sc-401769-ACT from Santa Cruz Biotechnology
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SIK1 CRISPR Activation Plasmid (h2) - sc-401769-ACT-2 from Santa Cruz Biotechnology
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SIK1 Lentiviral Activation Particles (h) - sc-401769-LAC from Santa Cruz Biotechnology
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SIK1 Lentiviral Activation Particles (h2) - sc-401769-LAC-2 from Santa Cruz Biotechnology
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SIK1 siRNA (h) - sc-91428 from Santa Cruz Biotechnology
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SIK1 shRNA Plasmid (h) - sc-91428-SH from Santa Cruz Biotechnology
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SIK1 shRNA (h) Lentiviral Particles - sc-91428-V from Santa Cruz Biotechnology
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SIK1/Snf1lk RNAi - H00150094-R03 from Novus Biologicals
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MISSION® esiRNA - EHU138711 from Sigma-Aldrich
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MISSION® siRNA - SIHK2094 from Sigma-Aldrich
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MISSION® siRNA - SIHK2096 from Sigma-Aldrich
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MISSION® siRNA - SIHK2095 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19340 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19340 from Sigma-Aldrich
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SIK1 siRNA (Human) - CRJ5639 from Cohesion Biosciences
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SIK1 - MBS8209347 from MyBioSource
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shRNA set against Human SIK1 (NM_173354.3) - SHH407524 from Creative biogene
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SIK1 CRISPR/Cas9 KO Plasmid (h2) - sc-401769-KO-2 from Santa Cruz Biotechnology
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SIK1 HDR Plasmid (h2) - sc-401769-HDR-2 from Santa Cruz Biotechnology
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SIK1 shRNA Plasmid (Human) - CHJ5639 from Cohesion Biosciences
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SIK1 miRNA 3'UTR clone - MiUTR1H-09689 from Creative biogene
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