| Gene Symbol | SIK1 |
|---|---|
| Entrez Gene | 150094 |
| Alt Symbol | MSK, SIK, SNF1LK |
| Species | Human |
| Gene Type | protein-coding |
| Description | salt-inducible kinase 1 |
| Other Description | SIK-1|SNF1-like kinase|myocardial SNF1-like kinase|salt-inducible protein kinase 1|serine/threonine protein kinase|serine/threonine-protein kinase SIK1|serine/threonine-protein kinase SNF1-like kinase 1|serine/threonine-protein kinase SNF1LK |
| Swissprots | A6NC84 Q6ZNL8 Q86YJ2 P57059 Q5R2V5 |
| Accessions | BAA95536 EAX09495 EAX09496 P57059 AB047786 BAD74070 AI073528 AK131076 BAC85126 BC038504 AAH38504 BM840872 CF528907 DQ892466 ABM83392 DQ895679 ABM86605 XM_011529474 XP_011527776 NM_173354 NP_775490 |
| Function | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expressi |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16306228}. Nucleus {ECO:0000269|PubMed:16306228}. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ. |
| Top Pathways | Glucagon signaling pathway |