| Gene Symbol |
ZNRF2
|
| Entrez Gene |
223082
|
| Alt Symbol |
RNF202
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc and ring finger 2, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase ZNRF2|RING finger protein 202|protein Ells2|zinc finger/RING finger 2|zinc/RING finger protein 2
|
| Swissprots |
Q8NHG8
|
| Accessions |
EAL24455 EAW93938 EAW93939 Q8NHG8 AF513707 AAQ08115 AF527533 AAM88868 AK025240 AY054122 AAL14867 BC172400 AAI72400 XM_011515217 XP_011513519 XM_011515218 XP_011513520 XR_926925 NM_147128 NP_667339
|
| Function |
May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14561866}.
|
| Subcellular Location |
Endosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Lysosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Note=Present in presynaptic plasma membranes in neurons.
|
| Tissue Specificity |
Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. {ECO:0000269|PubMed:14561866}.
|