Gene Symbol | ZNRF2 |
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Entrez Gene | 223082 |
Alt Symbol | RNF202 |
Species | Human |
Gene Type | protein-coding |
Description | zinc and ring finger 2, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase ZNRF2|RING finger protein 202|protein Ells2|zinc finger/RING finger 2|zinc/RING finger protein 2 |
Swissprots | Q8NHG8 |
Accessions | EAL24455 EAW93938 EAW93939 Q8NHG8 AF513707 AAQ08115 AF527533 AAM88868 AK025240 AY054122 AAL14867 BC172400 AAI72400 XM_011515217 XP_011513519 XM_011515218 XP_011513520 XR_926925 NM_147128 NP_667339 |
Function | May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14561866}. |
Subcellular Location | Endosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Lysosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Note=Present in presynaptic plasma membranes in neurons. |
Tissue Specificity | Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney. {ECO:0000269|PubMed:14561866}. |
ZNRF2 CRISPR/Cas9 KO Plasmid (h) - sc-408350 from Santa Cruz Biotechnology
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ZNRF2 HDR Plasmid (h) - sc-408350-HDR from Santa Cruz Biotechnology
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ZNRF2 Double Nickase Plasmid (h) - sc-408350-NIC from Santa Cruz Biotechnology
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ZNRF2 Double Nickase Plasmid (h2) - sc-408350-NIC-2 from Santa Cruz Biotechnology
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ZNRF2 CRISPR Activation Plasmid (h) - sc-408350-ACT from Santa Cruz Biotechnology
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ZNRF2 CRISPR Activation Plasmid (h2) - sc-408350-ACT-2 from Santa Cruz Biotechnology
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ZNRF2 Lentiviral Activation Particles (h) - sc-408350-LAC from Santa Cruz Biotechnology
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ZNRF2 Lentiviral Activation Particles (h2) - sc-408350-LAC-2 from Santa Cruz Biotechnology
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ZNRF2 siRNA (h) - sc-89499 from Santa Cruz Biotechnology
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ZNRF2 shRNA Plasmid (h) - sc-89499-SH from Santa Cruz Biotechnology
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ZNRF2 shRNA (h) Lentiviral Particles - sc-89499-V from Santa Cruz Biotechnology
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ZNRF2 RNAi - H00223082-R01 from Novus Biologicals
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MISSION® esiRNA - EHU134111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23784 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23784 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09979 from Sigma-Aldrich
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ZNRF2 siRNA (Human) - CRJ6589 from Cohesion Biosciences
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ZNRF2 - MBS829435 from MyBioSource
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shRNA set against Human ZNRF2 (NM_147128.3) - SHH455688 from Creative biogene
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Human ZNRF2 siRNA - orb277090 from Biorbyt
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ZNRF2 shRNA Plasmid (Human) - CHJ6589 from Cohesion Biosciences
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ZNRF2 miRNA 3'UTR clone - MiUTR1H-11748 from Creative biogene
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