| Gene Symbol |
CTU2
|
| Entrez Gene |
348180
|
| Alt Symbol |
C16orf84, NCS2, UPF0432
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytosolic thiouridylase subunit 2 homolog (S. pombe)
|
| Other Description |
cytoplasmic tRNA 2-thiolation protein 2
|
| Swissprots |
Q66K78 Q86SV4 Q0P511 B2RXK0 Q6P4C8 Q2VPK5
|
| Accessions |
EAW66775 EAW66776 EAW66777 EAW66778 EAW66779 EAW66780 Q2VPK5 AK299521 BAG61472 BC021056 BC021829 BC044951 BC063512 BC080540 AAH80540 BC108659 AAI08660 BC121805 AAI21806 BC125269 AAI25270 BC157881 AAI57882 BM554780 BQ430809 XM_011523068 XP_011521370 NM_001012759 NP_001012777 NM_001012762 NP_001012780
|
| Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Sulfur relay system
|
![Western Blot: CTU2 Overexpression Lysate (Adult Normal) [NBL1-08230] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CTU2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7642_CTU2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08230-img0002.jpg)